5-MeO-DiPT (5-methoxy-N,N-diisopropyltryptamine) has been preliminarily reported to exhibit short-term hallucinogenic effects on humans. However, the connection between its toxic mechanism and behavioral changes remains unexplored. Therefore, this study used zebrafish as the research subject to investigate the metabolic characteristics of 5-MeO-DiPT and its perturbation effects on the metabolic...
Novel Psychoactive Substances (NPS) derived from tryptamines has been detected in aquatic environments, leading to environmental toxicology concerns. However, the specific toxicological mechanism, underlying these NPS, remains unclear. In our previous work, we used 5-Methoxy-N-isopropyl-N-methyltryptamine (5-MeO-MiPT) as the representative drug for NPS, and found that, 5-MeO-MiPT led to obvious...
5-Methoxy-N-methyl-N-isopropyltryptamine (5-MeO-MiPT) is a novel psychoactive substance exhibiting a tryptamine structure. Despite its increasing prevalence, the environmental impact of 5-MeO-MiPT remains unexplored. Our prior investigation revealed that 5-MeO-MiPT induced inhibited spontaneous movement and prompted anxiety-like behavior in adult zebrafish-a validated toxicological model. To...