Lars Nyberg

2 papers in the library · publishing 2014-2018

Papers

The retrosplenial cortex: A memory gateway between the cortical default mode network and the medial temporal lobe.

Human Brain Mapping May 1, 2018 Neda Kaboodvand, Lars Bäckman, Lars Nyberg et al.

The retrosplenial cortex (RSC) acts as a critical gateway between the medial temporal lobe (MTL) and other cortical regions of the default mode network (DMN), supporting episodic memory in older adults. In 180 healthy adults aged 64-68, functional connectivity between MTL and RSC was stronger than between MTL and other DMN regions like the posterior cingulate cortex, and only MTL-RSC connectivity was significantly associated with episodic memory performance. Mediation analysis showed that MTL-cortical DMN connectivity increased with RSC as a mediator, and graph-theoretical analysis revealed the highest betweenness centrality for RSC. The degree of RSC mediation was associated with better episodic memory, indicating that individuals with greater mediation have a memory advantage.

DOI: 10.1002/hbm.23983 Full text Dmn Aging Betweenness centrality Episodic memory +3

Out-of-body-induced hippocampal amnesia.

Proceedings of the National Academy of Sciences of the United States of America March 25, 2014 Loretxu Bergouignan, Lars Nyberg, H Henrik Ehrsson

Episodic memory—the ability to recall personal experiences—depends on experiencing the world from the vantage point of one's own body. When an out-of-body illusion displaced participants' sense of bodily self away from their real body during a social interaction, their later recall of those events was worse compared to when the bodily self remained aligned with the real body. Brain imaging linked this memory impairment to altered activity in the posterior hippocampus. The findings indicate that a first-person, body-centered perspective is necessary for efficient hippocampus-based encoding of real-life events, with implications for understanding memory deficits in psychiatric disorders involving dissociation.

DOI: 10.1073/pnas.1318801111 Full text Autobiographical memory Body illusion Dissociative experience Self-consciousness