Meditation and De-Addiction: A Neurobiological Perspective
International Journal of Endovascular Treatment and Innovative Techniques December 26, 2025 Km Megha, Arjun Ram Roj, Vijay Shanker Yadav et al.
Addiction involves compulsive substance use and impaired self-regulation, driven by neurobiological changes in the prefrontal cortex, amygdala, hippocampus, and mesolimbic reward system that disrupt reward processing, cognitive control, and stress regulation, leading to heightened cravings and relapse vulnerability. Preliminary evidence suggests meditation may influence these systems by modulating prefrontal-limbic connectivity, normalizing stress responses via the HPA axis, and enhancing neuroplasticity. However, findings are mixed and limited by methodological shortcomings, precluding definitive conclusions. Rigorous controlled studies with standardized protocols, larger samples, and longer follow-ups are needed to establish clinical efficacy.