Along with the development of artificial-intelligence technology, the construction of machine consciousness has become a hot issue studied by scholars. Generally speaking, the research methods of machine consciousness are mainly divided into two approaches: the algorithm-construction strategy and the brain-like-construction strategy. The algorithm-construction strategy refers to the research of...
AlphaFold2 (AF2) models have had wide impact but mixed success in retrospective ligand recognition. We prospectively docked large libraries against unrefined AF2 models of the σ 2 and serotonin 2A (5-HT2A) receptors, testing hundreds of new molecules and comparing results with those obtained from docking against the experimental structures. Hit rates were high and similar for the experimental...