4 papers in the library · publishing 2019-2025
JAMA Psychiatry April 9, 2025 Jessica Ahrens, Sabrina D. Ford, Betsy Schaefer et al.
Cannabis use is associated with alterations in the midbrain dopamine pathway that is involved in psychosis. The findings suggest a link between cannabis and changes in this brain system, which may help explain the connection between cannabis use and the development of psychotic symptoms.
Neuroscience and Biobehavioral Reviews January 26, 2020 P. Frewen, M. Schroeter, G. Riva et al.
A review of neuroimaging research on self-referential processing (SRP) distinguishes between verbal and non-verbal forms, each occurring in controlled, top-down tasks (introspection and interoception) and in spontaneous, bottom-up states (mind wandering and body wandering during rest). The authors propose a conceptual and methodological framework for future SRP research, which they apply to understanding psychological and neurological disorders linked to abnormal SRP. The discussion draws on William James' writings on the consciousness of self.
bioRxiv November 2, 2019 R. Limongi, P. Jeon, M. Mackinley et al. preprint
Psychosis may arise from disrupted brain connectivity caused by insufficient NMDA receptor activity. In a study of 20 people with first-episode psychosis and 20 healthy controls, glutamate levels in the dorsal anterior cingulate cortex (dACC) were linked to altered inhibitory connections within the salience network. Specifically, higher glutamate correlated with weaker inhibitory influence on excitatory neurons in the dACC among those with psychosis. Abnormalities in cognitive-control task performance were tied to these disrupted connections, and the strength of connections from the dACC to the anterior insula was inversely related to social withdrawal severity. The findings suggest that glutamate-driven disinhibition contributes to connectivity deficits and cognitive impairments in psychosis.
Biological Psychiatry January 1, 2019 Kaustubh Supekar, Weidong Cai, R. Krishnadas et al.
Dynamic interactions between the salience network and two other large-scale brain networks—the central executive network and default mode network—are reduced, less persistent, and more variable in patients with schizophrenia compared with well-matched control subjects. These aberrant network dynamics distinguish patients from controls with 78% and 80% accuracy in two independent cohorts. Crucially, the degree of disruption correlates with positive psychotic symptoms but not with negative symptoms. The findings support an aberrant saliency model of psychosis, in which dysregulated time-varying engagement of the salience network contributes to the neurobiology of schizophrenia.