Four deaths are associated with the new designer stimulant 5-(2-aminopropyl)indole (5-IT), an indole derivative first synthesized in 1962. In three cases, 5-IT was detected in femoral blood at concentrations ranging from 0.4 to 10 mg/L, often alongside other drugs such as MDMA, 6-APB, amphetamine, and methylone. One death was attributed solely to 5-IT toxicity; two deaths were attributed to toxic cocktail effects of multiple drugs; and one death was attributed to drug toxicity with an indeterminate role of epilepsy. A validated high-performance liquid chromatography method for quantitating 5-IT is also reported.
Three psychoactive arylcyclohexylamines sold online as research chemicals were chemically identified: methoxetamine, N-ethyl-1-(3-methoxyphenyl)cyclohexanamine, and 1-[1-(3-methoxyphenyl)cyclohexyl]piperidine. A validated liquid chromatography method with ultraviolet detection reliably measured these compounds in blood, urine, and vitreous humor at concentrations from 0.16 to 5.0 mg/L, while mass spectrometry served as a confirmatory technique.