Science Advances
May 20, 2022
Tammi R. A. Kral, Kaley Davis, Cole Korponay et al.
67 citations
A large, rigorously controlled study failed to find evidence that an 8-week mindfulness-based stress reduction (MBSR) course changes brain structure. Combining data from two randomized controlled trials with 218 meditation-naïve participants, the study compared MBSR to an active control and a waitlist group. Using structural MRI scans before and after the intervention, researchers assessed gray matter volume, gray matter density, and cortical thickness. No neuroplastic changes were observed in the MBSR group compared to either control group, either across the whole brain or in regions previously reported to change. This contradicts widely referenced earlier claims that MBSR alters brain structure.
Scientific Reports
August 19, 2019
Cole Korponay, Daniela Dentico, Tammi R. A. Kral et al.
49 citations
An eight-week mindfulness intervention did not reduce impulsivity on the go/no-go task or Barratt Impulsiveness Scale (BIS-11), nor produce changes in neural correlates such as frontostriatal gray matter, functional connectivity, or dopamine levels compared to active or wait-list control groups. Long-term meditators (LTMs) did not differ from meditation-naïve participants (MNPs) on the go/no-go task, but LTMs self-reported lower attentional impulsivity and higher motor and non-planning impulsivity on the BIS-11. LTMs had less striatal gray matter, greater cortico-striatal-thalamic functional connectivity, and lower spontaneous eye-blink rate than MNPs. Total lifetime practice hours did not significantly relate to impulsivity or neurobiological metrics, suggesting pre-existing differences may account for group differences.
Scientific Reports
September 24, 2023
Tammi R. A. Kral, Helen Y. Weng, Vikramjit Mitra et al.
25 citations
Lower resting respiration rate (RR) may serve as a physiological marker of well-being, particularly among people who practice meditation. In a study of 245 adults, long-term meditators showed an association between lower RR and lower psychological distress. Mindfulness-based stress reduction (MBSR) decreased RR compared to a waitlist control, though not compared to an active control. Decreased RR was linked to fewer medical symptoms across all participants. After training, lower RR was associated with higher psychological well-being in training groups relative to waitlist, but there were no significant differences in change in well-being between groups. The findings suggest RR may indicate physical or psychological well-being in those who engage in wellness practices.
Brain Behavior & Immunity - Health
September 14, 2022
Estelle T. Higgins, Richard J. Davidson, William W. Busse et al.
20 citations
Mindfulness-Based Stress Reduction (MBSR) training improved asthma control and reduced airway inflammation in adults with asthma. In a randomized trial, 32% of MBSR participants achieved a clinically significant improvement in asthma control compared to 12% of wait-list controls, an effect maintained four months after the intervention. Improvement was linked to reduced distress and was greatest among those with higher baseline depressive symptoms. MBSR also lowered exhaled nitric oxide, a biomarker of airway inflammation. The findings suggest MBSR may benefit asthma management, especially for patients with psychological comorbidity.
Frontiers in Psychology
January 28, 2021
Dylan Thomas Lott, Tenzin Yeshi, N. Norchung et al.
18 citations
Recent EEG studies on the early postmortem interval suggest the persistence of electrophysiological coherence and connectivity in the brain of animals and humans, reinforcing the need for further investigation of brain activity during the dying process. Under the direction of the Center for Healthy Minds at the University of Wisconsin-Madison, research was conducted in India on a postmortem meditative state (tukdam) cultivated by some Tibetan Buddhist practitioners, in which decomposition is putatively delayed. For healthy baseline and postmortem subjects, resting state EEG, mismatch negativity, and auditory brainstem response data were collected. Living subjects displayed well-defined MMN and ABR responses, but no recognizable EEG waveforms were discernable in any of the tukdam cases.
Journal of Counseling Psychology
March 1, 2024
Kevin M. Riordan, Otto Simonsson, Corrina Frye et al.
12 citations
A two-week compassion-based meditation program delivered via the Healthy Minds Program app was tested in undergraduates with elevated depression or anxiety (N=351). Participants were randomly assigned to either one 20-minute meditation per day or two 10-minute meditations per day. Both groups showed improvements in psychological distress, experiential avoidance, fear of missing out, loneliness, and self-compassion from before to after the intervention, and daily distress and loneliness also improved over time. No significant differences were found between the two dosing schedules on any measure. When total daily meditation time is equal, distributing practice into shorter sessions does not affect outcomes for distressed beginners.
March 30, 2021
Matthew J. Hirshberg, Corrina Frye, Cortland J. Dahl et al.
5 citations
preprint
A four-week smartphone-based meditation app (Healthy Minds Program) reduced psychological distress and improved well-being among school system employees during the COVID-19 pandemic. In a randomized wait-list controlled trial with 662 participants (64% teachers), those assigned to the app showed significantly larger reductions in distress immediately after the intervention and at a three-month follow-up, with similar benefits on secondary outcomes such as perseverative thinking and social connection. The app was equally effective for participants with elevated baseline anxiety and depressive symptoms, and no evidence of elevated adverse events was found. The program may offer a scalable approach to supporting educator mental health.
February 19, 2023
Kevin M. Riordan, Otto Simonsson, Corrina Frye et al.
2 citations
preprint
A two-week compassion-based meditation intervention delivered via the Healthy Minds Program app led to improvements in psychological distress, experiential avoidance, fear of missing out, loneliness, and self-compassion among undergraduates with clinically elevated depression and/or anxiety. Participants were randomized to either one 20-minute meditation per day (Massed condition) or two 10-minute meditations per day (Distributed condition). Both groups showed similar improvements, with no significant differences between conditions on any outcome. When total daily meditation time is held constant, distributing practice across the day does not appear to influence outcomes for distressed beginners, supporting flexibility in meditation scheduling.
medRxiv
June 16, 2021
Tammi R. A. Kral, Kaley Davis, Cole Korponay et al.
2 citations
preprint
A large, rigorously controlled study combining data from two three-arm randomized controlled trials found no evidence that an eight-week Mindfulness-Based Stress Reduction (MBSR) course produces changes in brain structure. Meditation-naive participants (218 total) were randomly assigned to a waitlist, an 8-week MBSR program, or a validated active control group. Structural MRI scans taken before and after the intervention showed no significant differences in gray matter volume, gray matter density, or cortical thickness between MBSR and either control group, at either the whole-brain level or in brain regions previously linked to MBSR. These results fail to replicate earlier, widely cited claims of MBSR-induced neuroplasticity.
bioRxiv (Cold Spring Harbor Laboratory)
September 17, 2021
Tammi R. A. Kral, Regina C Lapate, Ted Imhoff‐Smith et al.
preprint
Long-term mindfulness meditation is associated with stronger resting-state functional connectivity between the posterior cingulate cortex and rostrolateral prefrontal cortex, lower connector hub strength of the default mode network relative to other networks, and better attention to task. In a sample of 40 long-term meditators (average 3,759 hours of practice) compared to 124 meditation-naïve controls, orienting attention positively correlated with posterior cingulate–rostrolateral prefrontal connectivity and negatively correlated with default mode network connector hub strength. These findings suggest that posterior cingulate–rostrolateral prefrontal connectivity may support attention orienting, consistent with a role for rostrolateral prefrontal cortex in meta-cognitive background awareness, a core component of mindfulness training.
Scientific Reports
May 18, 2026
Estelle T. Higgins, William W. Busse, Danika R. Klaus et al.
Mindfulness-based stress reduction (MBSR) training in adults with asthma reduced brain responses in the lateral prefrontal and orbitofrontal cortex when viewing emotional cues, and this reduction was linked to increased mindfulness. Decreased activity in the salience network after training was associated with lower psychological distress and less airway inflammation. Some of these brain and clinical changes persisted at a 6-month follow-up, while others did not. The findings indicate that MBSR promotes more efficient emotional processing and reduces reactivity, helping explain how mindfulness improves asthma control and inflammation through mind-brain-immune interactions.
Journal of Cognitive Neuroscience
August 1, 2022
Tammi R. A. Kral, Regina C Lapate, Ted Imhoff‐Smith et al.
Long-term mindfulness meditation is associated with stronger functional connectivity between the posterior cingulate cortex and rostrolateral prefrontal cortex, lower connector hub strength across the default mode network, and better subjective attention. In a sample of 40 long-term meditators averaging 3759 hours of practice, compared with 124 meditation-naive controls, orienting attention positively correlated with PCC-RLPFC connectivity and negatively correlated with default mode network connector hub strength. These results suggest that PCC-RLPFC connectivity may support attention orienting, a core component of metacognitive awareness trained in mindfulness meditation.