CNS DrugsJanuary 17, 2026Gaëlle Rached, Anna Campana, Dimitri Fiani et al.1 citation
Monoamine oxidase inhibitors (MAOIs) remain an important option for patients with treatment-resistant depression (TRD) and other psychiatric conditions, despite potentially serious drug-drug interactions and associated dietary tyramine restrictions. However, they are rarely prescribed in patients with comorbid substance use disorders (SUDs) due to concerns about potential drug interactions and...
Synthetic cathinones and phenethylamines are increasingly prevalent novel psychoactive substances with stimulant and hallucinogenic properties. They are associated with acute symptomatic seizures, often with lethal outcomes. Current management is usually limited to symptomatic therapy, as serotonin and sympathomimetic toxidromes are widely regarded as the main seizure-inducing mechanisms....
My findings show what causes loss of awareness, anesthesia, memory replay, opioid induced respiratory depression (OIRD), and slow wave sleep. Opiates are fast pain relievers and anesthetics that can cause respiratory arrest. I found how mu-opioids and anesthetics by activating medial habenula (MHb) and/or interpeduncular nucleus (IPN) induce unawareness and slowdown respiration. Using DTI...
MoleculesJanuary 8, 2026Anna W Sobańska, Andrzej M Sobański, Elżbieta Brzezińska1 citation
A total of 250 known and novel compounds-ketamine and serotonergic psychedelics or their analogues-designed to target depression, addictions and/or other mental or neurological disorders and developed as "recreational" (illegal) drugs from three chemical families, ergolines, tryptamines and phenylethylamines, were investigated in the context of their ability to cross the human placenta. Using a...
Psychedelics are a diverse class of psychoactive compounds that profoundly alter perception, cognition, and emotional states. Recently, classical serotonergic agents, such as psilocybin and lysergic acid diethylamide (LSD), along with atypical agents such as methylenedioxymethamphetamine (MDMA, ecstasy) and ibogaine, have attracted renewed attention due to their rapid and sustained clinical...
Adolescent mental health conditions, particularly treatment-resistant depression (TRD), represent a growing public health challenge associated with high morbidity, functional impairment, and elevated suicide risk. Psychedelic-assisted therapies have shown robust antidepressant and transdiagnostic effects in rigorously controlled adult trials. Extending this work to adolescents is scientifically...
JAMA Network OpenJanuary 2, 2026Gianluca Andri Florineth, Isabell Klima, Anna Laura Boeker et al.5 citations
Psychedelic-assisted therapy (PAT) is a novel intervention for depressive symptoms, typically delivered with additional psychological therapy sessions. Quantitative evidence on how this concomitant therapy contributes to treatment outcomes is limited, highlighting the need for a systematic synthesis. To evaluate whether the quantity of psychological therapy is associated with symptom reduction...
The last few decades have been characterised by a resurgence in research and clinical interest in classic serotonergic psychedelics including N,N-dimethyltryptamine (DMT), lysergic acid diethylamide (LSD) and psilocybin, with a growing body of literature pointing to their treatment potential. Ayahuasca is a psychedelic brew commonly composed of plants carrying the psychoactive compound DMT, and...
A growing number of studies suggest that serotonergic psychedelics, including lysergic acid diethylamide (LSD), can rapidly and lastingly stimulate various aspects of neuroplasticity. Neuroplasticity is the nervous system’s fundamental ability to reorganize itself in order to adapt to its environment, and it involves both changes in brain structure and changes in how the brain functions. It is...
Drug addiction is a complex, chronic, and relapsing neurological disorder characterized by persistent neuroadaptation and a substantial public health burden. Because of its simple nervous system, genetic tractability, short life cycle, transparent body, and quantifiable behavioral phenotypes, C. elegans (Caenorhabditis elegans) has become a useful complementary model for studying selected...