Mushrooms have been used in traditional medicine for centuries, although only relatively recently they have become a subject of intensive studies as a source of potential drugs and products that could be used in the treatment of many disorders. Mushroom-forming fungi are shown to produce a vast number of unique metabolites that exhibit various biological effects; these include polysaccharides,...
Background: Postpartum depression (PPD) is a major public health concern and has, at its core, a sense of maternal ‘disconnection’ – from the self, the infant, and the support system. While PPD bears similarities with MDD, there is increasing evidence for its distinct nature, especially with the unique aspect of the mother-infant relationship. Current treatment modalities for PPD, largely based...
CureusMay 27, 2022Robert Sotille, Herpreet Singh, Anne Weisman et al.2 citations
Current medications have not been effective in reducing the prevalence of mental illness worldwide. The prevalence of illnesses such as treatment-resistant depression has increased despite the widespread use of a broad set of psychopharmaceuticals. Transcranial magnetic stimulation and ketamine therapy are making great strides in improving treatment-resistant depression outcomes but they have...
Abstract Moral enhancement proposals struggle to be both plausible and ethically defensible while nevertheless interestingly distinct from both cognitive enhancement as well as (mere) moral education. Brian Earp ( Royal Institute of Philosophy Supplement 83:415–439, 12) suggests that a promising middle ground lies in focusing on the (suitably qualified) use of psychedelics as adjuncts to moral...
Over the past decade, there has been an increase in the number of clinical trials for psychedelic therapies as treatments for a wide range of psychiatric conditions. We are concerned that research organizations overseeing these trials have neglected the inclusion of individuals with physical and sensory disabilities. We suggest that psychedelic research organizations should prioritize and plan...
Therapy of existential distress of incurable patients is no less important task of palliative medicine than, in fact, relief ofphysical pain. At the same time, the unreliability of the means used in this field, noted by experts, forces us to pay attention to their al-ternative in the form of psychedelics-entheogens, whose therapeutic potential, judging by the content of world mythology, was...
Objective: Functional neurological disorder (FND) causes a high burden of disability and distress. Although it is a common disorder, there is a pressing need for improved access to evidence-based treatments. With difficulties in finding effective treatment, some people with FND may seek alternative means of symptom relief, such as legal and illicit psychoactive substances, although the...
Depression has long been recognized as a major public health problem.Fear and anxiety associated with the high morbidity and mortality of COVID-19 have increased risk factors for mental health decline.A high prevalence of psychiatric disorders has been documented in individuals who have been directly or indirectly exposed to life-threatening situations.Current evidence suggests decompensation...
Abstract Contemporary clinical research into the psychotherapeutic administration of psychedelics has primarily emphasized the importance of therapeutic interpersonal interactions to assist clients prepare for and integrate the acute effects of psychedelics. Alternative therapeutic frameworks have encouraged active talk therapy between therapists and clients during the administration phase. We...
In healthy adults, LSD produces little change in cognition, mood There have been numerous anecdotal reports of beneficial mood and cognitive effects from repeated administration of low doses of lysergic acid diethylamide (LSD) at intervals of 3 to 4 days, but few controlled studies have been conducted. Animal research has suggested that repeated low doses of LSD could confer antidepressant...