Psychedelic-assisted therapy (PAT) has shown promising results in alleviating psychological and existential suffering among individuals with serious illnesses. In parallel, nursing offers a robust theoretical framework to guide therapeutic communication in this context. This article explores the application of Peplau's Theory of Interpersonal Relations (PTIR) as a foundation for holistic...
Abstract Background: Major depressive disorder (MDD) is a significant public health concern, and current treatments often have limitations in effectiveness and adherence. Psilocybin, a psychedelic compound found in certain mushrooms, is being explored as a potential treatment for depression. It primarily acts through the serotonin 5-HT2A receptor but interacts with 5-HT1A and 5-HT2C receptors....
Professor Gregor Hasler stands at the forefront of revolutionary psychedelic research and neuroplasticity studies, transforming our understanding of mental health treatment through groundbreaking scientific discoveries. As Chair of Psychiatry at the University of Fribourg, Switzerland, where he directs the Molecular Psychiatry Lab, Hasler has pioneered research on how psychedelics like LSD,...
The potential use of psychedelic-assisted therapy for adolescents with mental illness has sparked both interest and concern. Modern psychedelic research has focused on adults, and adolescents younger than 18 years are typically excluded due to ethical and legal challenges. To explore whether adolescents have been included in 21st century psychedelic research, we conducted a scoping review of...
Major depressive disorder (MDD) is a complex and debilitating condition affecting approximately 280 million people worldwide. Its heterogeneous nature makes it difficult to establish clinical treatment guidelines that address individual differences in treatment response. As a result, many individuals experience treatment-resistant depression (TRD) failing to respond to first-line...
Anorexia nervosa (AN) is an eating disorder characterized by compulsive eating restrictions and cognitive inflexibility, which is linked to dysregulation within the cortico-striatal-thalamo cortical (CSTC) circuitry. Dysfunction within the dorsolateral prefrontal cortex and dorsal striatum has been implicated in habitual decision making and impaired cognitive flexibility, contributing to...
Psychotherapy with the use of psychedelics is an emerging field that evokes both curiosity and scepticism. This article explores how these substances, despite their controversial reputation, can have their therapeutic value within a systemic context. For centuries, psychedelics have been used for spiritual and healing purposes and received considerable scientific attention in psychiatry in the...
G protein-coupled receptors (GPCRs) represent key drug targets, with approximately 30%-40% of all medications acting on these receptors. Recent advancements have uncovered the complexity of GPCR signaling, including biased signaling, which allows selective activation of specific intracellular pathways-primarily mediated by G proteins and β-arrestins. Among aminergic GPCRs, the serotonin 5-HT2A...
After completing this activity, participants should be able to: Differentiate between the regulatory status, therapeutic applications, and clinical considerations of various psychedelic substances. Recognize and manage the safety considerations and potential risks associated with psychedelic-assisted therapy. Apply harm reduction principles when counseling patients who express interest in...
ABSTRACT Ketamine and esketamine are regularly prescribed in the United States as pharmaceutical interventions for treatment‐resistant depression. Although ketamine's mode of action is distinct from classic psychedelics, patients frequently report similar alterations in consciousness, including experiences described as spiritual or religious. This article provides an overview of the Ketamine...