Had you been a young boy in the 1960s and wanted to try for yourself the psychedelic experience written about in books such as The doors of perception, how would you have acquired the necessary 'drugs'?f-'AIJL DEVEKE~JX wrote to Aldous Huxley and amazingly Huxley replied.Whilst Huxley could not supply, in this case mescaline, he wished him well in his quest, and by his 21sl birthday two small...
While the hallucinogenic mushrooms Psilocybe semilanceata have previously been analyzed for the indole alkaloids psilocybin and baeocystin by capillary zone electrophoresis (CZE) at pH 11.5, the present work focused on the development of an alternative and complementary capillary electrophoretic method for their identification. Owing to their structural similarity and zwitterionic nature, the...
Salvia divinorum Epling & J. Tiva-M. is a member of the mint family (or Lamiaceae) native to the mountains of Oaxaca, Mexico. It is used by the Mazatec Indians of the region, in a manner similar to psilocybian mushrooms and lysergic acid-containing morning glory seeds, as a ritual entheogen (hallucinogen) and divinatory aid. It is propagated vegetatively by the Mazatecs, and no wild specimens...
In 1996 samples of suspicious honey preparations were confiscated at the Dutch-German border. The labels on the 50 ml jars indicated that the honey contained Stropharia cubensis (better known as Psilocybe cubensis). The jars were filled with honey with a ca. 1 cm layer of fine particles on the top. The particles were collected and subjected to microscopic and chemical analysis. By microscopy...
An important determinant of the neurobehavioral responses induced by a drug is its relative receptor selectivity. The molecular basis of ligand selectivity of hallucinogenic and nonhallucinogenic compounds of varying structural classes for the human 5-hydroxytryptamine (5-HT)2A and 5-HT2C receptors was investigated with the use of reciprocal site-directed mutagenesis. Because these two closely...
Psilocybin is investigated as a fast-acting antidepressant used in conjunction with psychotherapy. Intact cognitive functions, including memory, are one of the basic conditions of effective psychedelic-assisted therapy. While cognitive and memory processing is attenuated on various domains during psilocybin intoxication, the effect of psilocybin on the consolidation of memories learned outside...
An update is given on there corded psilocybin - and ibotenic acid containing mushrooms on a worldwide scale. Many new psilocybian species have been discovered during the last 15 years, including representatives of the genera Psilocybe, Panaeolus, Inocybe, Gymnopilus and Pluteus, whereas only Amanita regalis was identified as a new and potent source of ibotenic acid. Recreational use of...
Several specimens of Psilocybe and Copelandia species in Koh Samui, Thailand were recently collected for herbarium deposit and scientific study. This paper presents an ethnomycological and biochemical study of one of the species; P. samuiensis Guzmán, Bandala and Allen, a new psychoactive gill fungus reported from Thailand. Mycelium for the cultivation of P. samuiensis was obtained on 6% malt...
SOME EFFECTS OF GROUP DRUG TAKING ERWIN DI CYAN* The purpose of this paper is to discuss briefly some aspects of the differences between drug effects when drugs are used in groups as distinguished from their solitary use. The human organism responds to a variety of stimuli. Its response to signals may be physiological or psychological. The latter response includes recollections by (a) retrieval...
Abstract The occurrence and extraction of indole derivatives in six species from four genera of higher fungi were investigated. By using pure methanol for extraction of the mushrooms analysis revealed the highest concentrations of psilocybin and baeocystin. The psilocin content of the species was higher by using aqueous solutions of alcohols than with methanol alone but was an artificial...