In Harvard’s Quixotic Pursuit of a New Science, Patrick L. Schmidt tells the little-known story of how some of the most renowned social scientists of the twentieth century struggled to elevate their emerging disciplines of cultural anthropology, sociology, and social and clinical psychology. Scorned and marginalized in their respective departments in the 1930s for pursuing the controversial...
A depressão é uma doença que acomete cerca de 3,4% da população mundial e para a qual, até hoje, existem diversas barreiras para que se possa alcançar a cura. Os tratamentos atuais baseiam-se em medicação antidepressiva, sendo de primeira escolha, na maior parte dos casos, a classe dos inibidores seletivos da recaptação de serotonina (ISRS). No cenário de utilização da farmacoterapia com...
Terminally ill patients may experience existential distress, depression, or anxiety, limiting quality of life in the final stage. Existing psychotherapeutic or pharmacological interventions have (time) limited efficacy. Psychedelic treatment may be a safe and effective alternative treatment option. Systematically review studies on psychedelic treatment with and without psychotherapy for...
The 21st century has seen a dramatic flow and ebb in the fortunes of clinical psychopharmacology particularly with regard to antidepressants. For about 20 years, perhaps from about 1985 onwards, the tide flowed in with many ‘new’ drugs being made available to clinicians. In mood and psychotic disorders, these were essentially incremental advances from old drugs such as amitriptyline and...
A 49-year-old woman was diagnosed with an ER + , PR-, HER2 + , BRCA- invasive ductal carcinoma which progressed metastatically to include bone, liver, and lymph node involvement. Standardised care included a 26-month treatment period with targeted chemotherapy and a ketogenic diet. The patient also began a course of cannabinoid-based therapy, consisting initially of a titrated high-dose...
In Harvard’s Quixotic Pursuit of a New Science, Patrick L. Schmidt tells the little-known story of how some of the most renowned social scientists of the twentieth century struggled to elevate their emerging disciplines of cultural anthropology, sociology, and social and clinical psychology. Scorned and marginalized in their respective departments in the 1930s for pursuing the controversial...
The recent surge in recreational (non-medical) use of nitrous oxide (N 2 O, also known as ‘laughing gas’) often by inhaling it from balloons, has attracted the attention of some politicians with calls to control its possession under the United Kingdom (UK) Misuse of Drugs Act 1971 (currently selling, but not possession, for recreational use is controlled under the Psychoactive Substances Act...
Preliminary evidence supports the use of psychedelics for major depressive disorder (MDD). However, less attention has been given to the neural mechanisms behind their effects. We conducted a systematic review examining the neuroimaging correlates of antidepressant response following psychedelic interventions for MDD. Through MEDLINE, Embase, and APA PsycINFO, 187 records were identified and 42...
A psilocibina é um composto psicodélico de ocorrência natural produzido por mais de 200 espécies de fungos. Os mais potentes são membros do gênero Psilocybe, como P. azurescens, P. semilanceata e P. c
Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), dimethyltryptamine, and mescaline, and entactogens/empathogens, especially 3,4-methylenedioxymethamphetamine, have received renewed attention in psychiatric research and may be developed into medications for such indications as anxiety, depression, cluster headache, and posttraumatic stress disorder, among others....