BACKGROUND: The use of psychedelics is currently increasing in the United States. Awareness of clinical trials investigating the therapeutic applications of psychedelics may result in a record number of people who use psychedelics for the first-time. This study aimed to develop a harm-reduction resource to facilitate safe and successful psychedelic experiences outside of regulated clinical and...
DescriptionThis preprint proposes a new biological classification for N,N-dimethyltryptamine (DMT): crisis-linked endogenous consciousness modulators (cECMs). Using six mechanistically grounded, falsifiable criteria—endogenous neural biosynthesis, deep evolutionary conservation, ultra-rapid pharmacokinetics, multi-receptor promiscuity, crisis-linked release, and induction of information-rich...
November 20, 2025Christian Lloyd R. Evangelista, Angeles M. de Leon, Thomas Edison E. Dela Cruz
AbstractEthnomycology studies how people, particularly indigenous cultures, engage with fungi, including their use for food, medicine, crafts, and cultural rituals and beliefs. This field investigates the traditional knowledge that indigenous cultures have accumulated and passed down over generations, including their distinct methods of identifying, using, and appreciating various fungi....
Recent antidepressant drug development focuses on a next generation of drugs to rapidly relieve symptoms. Yet, how ketamine, the prototype rapid-acting antidepressant, maintains symptom relief days after drug elimination, and how repeated doses sustain longer-lasting therapeutic effects, remains unclear. Derived from elements of metaplasticity (synaptic priming), this review discusses a...
Alcohol use disorder (AUD) drives alcohol-associated liver disease (ALD), and relapsing after abstinence remains a significant challenge before and after transplantation. This review summarizes evidence for pharmacotherapies in relapse prevention and their integration into ALD care. Naltrexone and acamprosate reduce the relapse in the general AUD population, though data in ALD are limited....
November 17, 2025Tony R. Montgomery, Demond M. Grant
Recent research into classical psychedelics, such as psilocybin, LSD, and DMT, has highlighted their therapeutic potential for mental health disorders. However, emerging evidence suggests their utility may extend beyond treatment into the realm of preventive medicine. This manuscript proposes a novel framework positioning psychedelics as agents of cellular and psychological rejuvenation....
Serotonergic psychedelics, particularly psilocybin, lysergic acid diethylamide (LSD), and dimethyltryptamine (DMT), are increasingly recognised as powerful tools to advance the understanding of consciousness and its relation to brain activity. Psychedelic research has informed neuroscientific theories that attempt to map neural observations of network connectivity and signal diversity to...
The meta-analysis of the 11-dimensional Altered States of Consciousness (11D-ASC) included three studies that contained duplicated data from other papers: Duerler et al. (2021), Lewis et al. (2017), and Preller et al. (2017). When these studies are removed from the analysis, the results are generally similar to the previously reported findings. Out of 33 comparisons (3 doses x 11 dimensions)...
CureusNovember 12, 2025Aung Phyo Oo, Sarah Tseu, Arvind Ponnusamy
Magic mushroom poisoning can be associated with acute kidney injury (AKI), primarily due to ischemic acute tubular necrosis (ATN). Additionally, the use of cocaine can lead to both venous and arterial thrombosis through its vasoconstrictive and prothrombotic effects. In this article, a middle-aged gentleman with a previous history of cocaine use was admitted with severe anuric AKI requiring...