BACKGROUND: Psychedelics such as 3,4-methylenedioxymethamphetamine (MDMA) and psilocybin are showing promising results in clinical trials for the treatment of mental health disorders, including post-traumatic stress disorder, addiction, and treatment-resistant depression. US Food and Drug Administration approval may be on the horizon. Yet, little is known about how these treatments will move...
INTRODUCTION: Sertonergic psychedelics LSD, psilocin and DMT, have been shown to hold a great potential for treatment of various neuropsychiatric conditions, such as major depressive disorder, addiction, and end-of-life anxiety. Effects of these substances on neuronal activity and plasticity have been demonstrated, however, better understanding of their mechanism of action is crucial for...
Laws to control drugs have been progressively introduced since the early twentieth century to reduce non-medical use and drug-associated harm. Restrictions on what are now deemed ‘controlled drugs’ and, in New Zealand, ‘prohibited plants’ unjustly impact both medical care and research. The impact on research has frequently been cited in reference to the use of drugs in clinical research, such...
Psychedelic substances reliably occasion transient self-transcendent states, including mystical-type experiences, which are theorized to support salutogenic psychological change and long-term well-being. Despite growing interest in these phenomena, little is known about how acute self-transcendent states translate into enduring trait-level changes, or whether individual differences such as...
Les psychothérapies assistées par psychédéliques (PAP), en anglais Psychedelic-Assisted Therapies (PAT), sont des thérapies qui supposent le recours à des substances psychotropes, telles que la psilocybine ou le LSD. En plein essor, ces psychothérapies assistées par psychédéliques semblent efficaces dans les cas de troubles dépressifs sévères ou de détresse existentielle. S’appuyant sur un...
Farmacja PolskaDecember 30, 2025Ewa Niedzielska-Andres, Angelika Ziaja, Stanisław Zielinski et al.
Przedmiot badań: W ostatnich latach obserwuje się rosnące zainteresowanie wykorzystaniem naturalnych halucynogenów w leczeniu zaburzeń psychicznych, uzależnień czy bólu. Substancje takie jak psylocybina, ayahuasca, ibogaina czy meskalina poddawane są ocenie w badaniach klinicznych, które wskazują na ich potencjał terapeutyczny, zwłaszcza w leczeniu depresji lekoopornej, zespołu stresu...
High School in Lower Merion Township, Pennsylvania, where he was elected senior class president.He then attended Harvard College, initially intending to study astronomy.But after learning about the controversial experiments with psilocybin conducted by psychology professor Timothy Leary and his colleagues, he became interested in the function of the human brain, and graduated Magna Cum Laude as...
This is a companion review article to a narrative medicine story in this issue of the journal. “In The Ring” is a true story of a patient’s father’s near-death experience of Hell and the history of its follow up impact on the patient and her doctor. This article explores the medical perspective on NDE’s. How are NDE’s different from other altered mental states? What about deep anesthesia...
Psychedelic-assisted therapy (PAT) has emerged as a promising and innovative approach to treating a range of mental health disorders, including depression, post-traumatic stress disorder (PTSD), and substance use disorders. Once sidelined due to regulatory bans and social stigma, psychedelics such as psilocybin, 3,4-methylenedioxymethamphetamine (MDMA), lysergic acid diethylamide (LSD), and...
Introduced in 2014 and revised in 2018, the entropic brain hypothesis has accrued a wealth of supportive evidence. The hypothesis states that-along a dimension of the size of phenomenal consciousness-expansive states reliably exhibit increased brain entropy whereas the inverse applies for states of no or reduced consciousness. Examples of expansive states include expert meditation, flicker...