Zusammenfassung Substanzkonsumstörungen (SUD) sind chronische Erkrankungen mit hohen Rückfallraten und begrenzter Wirksamkeit etablierter Behandlungen. Vor diesem Hintergrund rückt die psychedelisch-assistierte Psychotherapie (PAP) mit Psilocybin und LSD zunehmend in den Fokus; die Literatur berichtet Hinweise auf mögliche Effekte insbesondere bei AUD und affektiven Symptomen. Ziel der Studie:...
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic-assisted therapy, using substances such as psilocybin and 3,4-methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including depression, anxiety and post-traumatic stress...
WorldviewsMay 7, 2026Annalisa Butticci, Osiris García Cerqueda
In Huautla de Jiménez, in the Mexican Sierra Mazateca, sacred mushrooms known as the Niños Santos (Holy Children) are openly sold in the psychedelic tourism market. Yet Mazatec healers lament that these sacred fungi are becoming increasingly difficult to find for healing ceremonies known as veladas . Faced with the extractive logics shaping global psychedelic circuits, the Niños Santos are said...
The past two decades have seen a remarkable renaissance in research on psychedelic drugs and ketamine. Following decades of regulatory restriction that severely limited, especially clinical research, a growing body of evidence has shown that psychedelics such as lysergic acid diethylamide and psilocybin can have long-lasting beneficial effects for treatment-resistant depression, drug and...
Mangoni, V. & Robledo, L. (Directors). Compuesto, Alexandra ‘Sasha’ (Producer). 2020. The Song that Calls You Home. Good Docs. 72 mins. The Song That Calls You Home is an informative documentary on plant medicine that focuses on the perceived therapeutic properties of ayahuasca. The film presents itself as an exploration of this psychedelic plant as a pathway to healing and self-discovery. Its...
Major depressive disorder (MDD) remains a global health burden, with over 60% of patients failing to respond adequately to current treatments. Treatment-resistant depression (TRD), a form of MDD, highlights the urgent need for mechanistically novel antidepressants. Psychoplastogens—a class of fast-acting compounds that promote neuroplasticity—are emerging as promising alternatives to...
Cancer ReportsMay 1, 2026Sepideh Hajivalizadeh, Kimia Farahmand, Kimia Kazemzadeh et al.
Depression is a prevalent comorbidity in cancer, yet conventional treatments show inconsistent efficacy. This review sought to provide a mechanism-based framework for managing cancer-related depression by exploring its unique pathophysiology and evaluating promising pharmacotherapies based on their alignment with these biological pathways. This narrative review synthesized evidence on promising...
Existing tools assess psychedelic experiences, but none specifically measure altered processing of traumatic memories-a key mechanism in trauma-focused therapies and psychotherapy in general. The helioscope effect describes how psychedelics like psilocybin and 3,4-methylenedioxymethamphetamine (MDMA) enable revisiting challenging or traumatic experiences while remaining protected from...