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2021 Natasha Leigh Mason
Cannabis is the most commonly used illicit drug and is known to alter state of consciousness and impair neurocognitive function. However, the mechanisms underlying these effects have yet to be fully elucidated. Rodent studies suggest that 9-tetrahydrocannabinol (THC) activates dopaminergic neurons in the limbic system, subsequently enhancing dopamine, which is implicated in the rewarding...
Progress in Brain Research 2021 Guy A. Higgins, Edward M. Sellers 10 citations
Nicotine use and dependence, typically achieved through cigarette smoking, but increasingly through vape products, is the leading cause of preventable death today. Despite a recognition that many current smokers would like to quit, the success rate at doing so is low and indicative of the persistent nature of nicotine dependence and the high urge to relapse. There are currently three main forms...
December 11, 2020 Balázs Szigeti, Laura Kärtner, Allan Blemings et al. 1 citation
Article Figures and data Abstract eLife digest Introduction Materials and methods Results Discussion Appendix 1 Data availability References Decision letter Author response Article and author information Metrics Abstract Microdosing is the practice of regularly using low doses of psychedelic drugs. Anecdotal reports suggest that microdosing enhances well-being and cognition; however, such...
Journal of Mental Health Counseling October 1, 2020 Russ Curtis, Lisen C. Roberts, Elizabeth Graves et al. 28 citations
Psychedelics (i.e., ketamine, methylenedioxymethamphetamine, psilocybin) have been effectively used globally for centuries to treat mental health and addiction issues. However, in the 1950s–1970s, a number of factors, including misuse, abuse, and poorly conceptualized and conducted clinical trials, caused the Federal Drug Administration to classify most of the psychedelic substances as having...
Journal of Psychedelic Studies June 1, 2020 Edward Jacobs 12 citations
Abstract The recent revivification of interest in the therapeutic use of psychedelics has had a particular focus on mood disorders and addiction, although there is reason to think these drugs may be effective more widely. After outlining pertinent aspects of psilocybin and obsessive-compulsive disorder (OCD), the current review summarizes the evidence indicating that there may be a role for...
Neuropsychopharmacology May 5, 2020 Marcus W. Meinhardt, Cansu Güngör, Ivan Skorodumov et al. 66 citations
For most psychiatric disorders, including alcohol use disorder (AUD), approved pharmacological treatments are limited in their effectiveness, and new drugs that can easily be translated into the clinic are needed. Currently, great hope lies in the potential of psychedelics to effectively treat AUD. The primary hypothesis is that a single session of psychedelic-guided psychotherapy can restore...
Psychopharmacology May 1, 2020 Toby Lea, Nicole Amada, Henrik Jungaberle et al.
The regular consumption of very small doses of psychedelic drugs (known as microdosing) has been a source of growing media and community attention in recent years. However, there is currently limited clinical and social research evidence on the potential role of microdosing as therapies for mental and substance use disorders. This paper examined subjective experiences of microdosing...
Proceedings of the National Academy of Sciences April 13, 2020 Morten L. Kringelbach, Josephine Cruzat, Joana Cabral et al. 326 citations
Significance In a technical tour de force, we have created a framework demonstrating the underlying fundamental principles of bidirectional coupling of neuronal and neurotransmitter dynamical systems. Specifically, in the present study, we combined multimodal neuroimaging data to causally explain the functional effects of specific serotoninergic receptor (5-HT 2A R) stimulation with psilocybin...
Psychiatric News March 20, 2020 Katie O’connor
Back to table of contents Previous article Next article Clinical & ResearchFull AccessCan Psychedelics Radically Change SUD Treatment?Katie O'ConnorKatie O'ConnorPublished Online:20 Mar 2020https://doi.org/10.1176/appi.pn.2020.2a12AbstractThough the field is young, psychedelics appear to hold promise as a treatment for addiction, even as barriers to research persist.iStock/agsandrewResearchers...
March 1, 2020 Adam Winstock, James W. Rucker 29 citations
Abstract Psychedelics and hallucinogens represent some of the most commonly used drugs in the world, with a history of use steeped in spirituality, counter-culture, and more recently latent therapeutic potential. Sharing a common mechanism of action at the 5-HT2a receptor, drugs such as lysergic acid diethylamide (LSD) and psilocybin, while they can rarely induce significant short-term...