Journal of Clinical Investigation
November 1, 2005
Wen Jiang, Yun Zhang, Lan Xiao et al.
The hippocampal dentate gyrus in the adult mammalian brain contains neural stem/progenitor cells (NS/PCs) capable of generating new neurons, i.e., neurogenesis. Most drugs of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown. This study aimed at investigating the potential regulatory...
Nature Neuroscience
June 2004
Susana Mato, Vivien Chevaleyre, David Robbe et al.
Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated...
American Journal of Clinical Hypnosis
2003
Ernest Lawrence Rossi
16 citations
The historical lineage of therapeutic hypnosis in James Braid's "psychophysiology", Pierre Janet's "physiological modification", and Milton Erickson's "neuro-psycho-physiology" is extended to include current neuroscience research on activity-dependent gene expression, neurogenesis, and stem cells in memory, learning, behavior change, and healing. Three conditions that optimize gene expression...
Juan Scherngell
preprint
This study presents a theoretical model analyzing the Sudama Cave as a purpose-built acoustic resonator. The chamber's dimensions (10.0 × 6.0 × 3.6 m) generate a dominant standing wave at 34.4 Hz, aligning with the resonant frequency of the human thoracic cavity. We argue this creates a biomechanical feedback loop, stimulating the vagus nerve and promoting neuroplastic adaptations associated...
Iftikhar Mahmud
preprint
This paper develops an integrated model of human consciousness and moral cognition grounded in Islamic anthropology. Drawing on the Qur’an, authenticated prophetic traditions, and classical Islamic scholarship, the study synthesizes key concepts—including rūḥ (divine life-principle), fiṭrah (innate moral orientation), nafs (impulse-bearing self), qalb (locus of moral awareness), and ʿaql...
Ziming Li, Crystal Weber, Francesca Sellitti et al.
Abstract A single dose of psilocybin can induce long-lasting antidepressant effects. The neurobiological mechanisms underlying such sustained antidepressant effect remain insufficiently understood, particularly at the level of synaptic function and drug-target specificity. Here, we aimed to delineate single-dose psilocybin-induced excitatory synaptic plasticity. Synaptic plasticity was assessed...
Juliana Yordanova
preprint
Abstract The experience of pain is a combined product of bottom-up and top-down influences mediated by attentional and emotional factors. Meditation states and traits are characterized by enhanced attention/emotion regulation and expanded self-awareness that can be expected to modify pain processing. The main objective of the present study was to explore the effects of long-term meditation on...
Anna Stefania Trippel, Ladina Philomena Gubser, Etna Jennifer Elektra Engeli et al.
preprint
Abstract Background: Cocaine is the most frequently used stimulant worldwide, with increasing consumption rates in Europe. Cocaine use is associated with great harm to individuals and society. As of today, psychotherapeutic interventions for cocaine use disorder (CUD) demonstrate only modest effect sizes, and no pharmacotherapy has been approved due to gaps in understanding the disease....
Behavioural Pharmacology
October 13, 2026
Bart A. Ellenbroek, Beth Naylor, Jiun Youn
Psilocybin has emerged as a promising therapeutic agent, with clinical benefits attributed to enhanced neuroplasticity rather than acute pharmacological effects. However, the fundamental mechanisms underlying these effects remain poorly understood. Using planarians as a model system, we investigated whether psilocybin enhances associative learning using a conditioned place preference paradigm....
Molecular Neurobiology
October 12, 2026
Daiane Momo Daneluz, Alana Sueli Dos Santos, Silvana Regina De Melo et al.
Psychedelic drugs promote rapid neuroplasticity in brain regions affected by trauma exposure, such as the prelimbic (PL) cortex and the dorsal hippocampus (DH), being investigated as potential treatments for posttraumatic stress disorder. Ayahuasca (Aya) contains N,N-dimethyltryptamine, a classic psychedelic. Our previous work showed that Aya reduces fear expression by impairing fear memory...