This study is the first to formally evaluate in humans the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of RE104, a prodrug of the synthetic psychedelic known as 4-hydroxy-N,N-diisopropyltryptamine or 4-OH-DiPT. This double-blind, randomized, placebo-controlled, phase 1 study of single subcutaneous (SC) doses of RE104 (5 to 40 mg) included 6 cohorts and a total of 48...
This thesis develops an understanding of the Pratyahara Paradox. Pratyahara (withdrawal of the senses) is a core tenet of yoga philosophy. Through pratyahara, a yoga practitioner can transcend the material world and unite with spiritual consciousness. While a withdrawal from the sensory-material world is embedded in the aims of yoga, it isn’t clear how, and if, pratyahara is part of...
Classic psychedelics, such as psilocybin and LSD, evoke certain kinds of altered states of consciousness. Specific features of the experience, such as its allegedly ineffable nature, have been discussed as posing challenges to the informed consent process. A growing call for tailored informed consent documents (ICDs) in the psychedelic bioethics literature raises the question of how closely...
The Thracians are present in the historiography of closed societies with some of the earliest records of aristocratic male communities inaccessible to the entire society. The origins of closed societies are rooted in their religious beliefs and initiation rites. This study focuses on the scarce sources of Thracian closed societies: they were built on a clan and social principle, with initiated...
Psychedelic drugs have been used for centuries all around the world for recreational purposes and in religious and healing practices as means to mystical experiences that lead to healing, insight a...
The general public is largely aware of meditation, and there is compelling evidence the practice has health benefits. But many people who are aware of meditation have not tried it, and those who do often struggle to establish a regular practice. The barriers to meditation are generally understood and include a lack of knowledge, a lack of time, and unclear benefits. These barriers present an...
Both psychedelic substances and meditation have been proposed to facilitate personally meaningful and transformative experiences, with insights playing a central role. However, previous research has mainly relied on questionnaires, limiting the range of insights that can be identified. In this study, we recruited participants who provided narrative reports of insights in personally meaningful...
Society’s deep divisions, fueled by individualism, competition, consumerism, rigid ideologies, and limited dialogue, have impacted health care, leading to weakened connections between providers and patients. In the U.S., heavy reliance on medical technology and the rise of AI have further eroded these intersubjective bonds, reducing empathetic engagement in care. To address this challenge, the...
This study evaluated the attitudes, knowledge, and educational experiences of psychiatry residents regarding psychedelics and psychedelic-assisted therapy (PAT). In 2023, we distributed an anonymous survey to United States psychiatry residents, assessing demographics, knowledge, and opinions on psychedelics/PAT. The survey also included items asking respondents to retrospectively self-report...
: Background: For families, especially mothers, the birth of a newborn with congenital defects is frequently difficult and unexpected experience. Purpose: To identify the effect of mindfulness-based stress reduction program on psychological distress, attachment, coping and caring behavior of mothers of neonates with congenital anomalies. Setting : The study was conducted at neonatal intensive...