Depressive disorder is a widespread psychological condition. It affects approximately 5% of adults globally. Untreated depression can compromise the quality of life in all its aspects, leading to deterioration of physical health or even suicide. Currently, the recommended treatment is pharmacological therapy, however, not all patients respond to traditional methods, and drug treatment is...
CellsNovember 26, 2025Ivan Anchesi, Maria Francesca Astorino, Ivana Raffaele et al.1 citation
Multiple Sclerosis (MS) therapies effectively modulate peripheral immune responses but largely fail to promote neural repair within the central nervous system. This review evaluates whether psychedelic compounds (PSYs), via 5-HT2A activation, can fill a critical therapeutic gap: the need for agents that simultaneously suppress neuroinflammation and promote regeneration. We dissect the evidence...
Abstract: This article applies approaches from current emotion research on material affective scaffolds—objects made and used to enhance, and more generally transform, affective states—to the emerging field of study focusing on emotions in ancient Near Eastern societies. Its main goal is to extend the framework of 4E cognition—with its central notion that human cognition is embodied, embedded,...
In addition to evidence supporting the use of psychedelics in treating alcohol and tobacco misuse, emerging research suggests that psychedelic experiences may also facilitate beneficial changes in other health behaviors, such as diet, exercise, and meditation. This retrospective, survey-based study explored perceived health behavior changes following psychedelic experiences, from the...
The Recursive Self-Presence Framework (RSF) proposes a functional and falsifiable architecture for the emergence of self-presence in synthetic systems.Rather than defining consciousness in metaphysical terms, RSF identifies four structural elements-Recursive Self-Modeling , Continuity , Valence Mapping , andAdaptive Action Loops -that must operate as a closed recursive holon for a system to...
This essay argues that Dr. Frank J. Tipler's Omega Point theory more parsimoniously aligns with universal apotheosis than the Abrahamic God, given life's unfairness and undeserved suffering, which suggest that all beings achieve godhood across infinite multiversal possibilities rather than relying on a singular entity that equally cares for all. Supporting this, the CIA's Gateway Process favors...
Psychedelics, such as psilocybin, reorganise large-scale brain connectivity, yet how these changes are reflected across electrophysiological (electroencephalogram, EEG) and haemodynamic (functional magnetic resonance imaging, fMRI) networks remains unclear. We present Brain-MGF, a multimodal graph fusion network for joint EEG-fMRI connectivity analysis. For each modality, we construct graphs...
The nature, location and functioning of the human mind remain contentious topics among philosophers, psychologists, linguists and AI researchers. Noam Chomsky, a pivotal figure in the cognitive revolution, offers a comprehensive framework for understanding the mind’s structure, processes and interactions with cognitive modules. This paper explores Chomsky’s perspective on the mind’s capacities,...
Abstract This article presents a case for engaging with fictional narratives to teach philosophical concepts, specifically exploring Christopher Nolan’s Memento to teach concepts related to Andy Clark and David Chalmers’ ‘The Extended Mind Thesis’ (EMT). I contrast a ‘theoretical’ approach to teaching EMT—that is, teaching these concepts by engaging directly with Clark and Chalmers’ text—with...
This paper formulates a possible embodied account of consciousness by integrating the vantages of ancient Chinese philosophy and medicine and predictive processing theories in cognitive science. It draws on robust empirical evidence from across the cognitive sciences, including contemporaneous work in philosophy of mind, neuropsychiatry, clinical psychology, and cognitive neuroscience to build...