Pharmacology, Biochemistry, and Behavior
1997
Richard A Glennon, R Young, Małgorzata Dukat et al.
48 citations
The phenylisopropylamine PMMA or N-methyl-1-(4-methoxyphenyl)-2-aminopropane, a structural hybrid of paramethoxyamphetamine (PMA) and methamphetamine, has been previously shown to unexpectedly lack amphetamine-like or hallucinogen-like stimulus properties in animals. For example, in tests of stimulus generalization, neither a (+)amphetamine stimulus nor a DOM stimulus generalized to PMMA. It...
Fortschritte der Neurologie · Psychiatrie
December 1996
L Hermle, Euphrosyne Gouzoulis‐mayfrank, M Spitzer
The concepts of intoxication, intoxication psychosis, and drug-induced psychosis are frequently used to refer to psychopathological states caused by the intake of hallucinogenic substances. The considerable increase of intoxications with substances of the chemical class of amphetamines (in particular, "Ecstasy") in western countries should cause major concern. Moreover, the number of...
Medieval Feminist Newsletter
September 1, 1996
Amy Hollywood
Ulrike Wiethaus' ambitious goal is to make medieval mysticism intellectually accessible to a modem western audience (2).To do this, she draws analogies between modem psychologies open to the existence and significance of "altered states of consciousness" and the accounts of ecstasies and visions within Mechthild of Magdeburg's The Flowing Light of the Godhead.The study is divided into two...
BMJ
August 17, 1996
David Shewan, Phil Dalgarno, Leslie A. King
14 citations
EDITOR,—There is increasing concern over the toxic1 and neurodegenerative2 effects of ecstasy, and further research is clearly required. Potential hazards can also, however, arise through use of tablets sold as ecstasy that contain substances other than ecstasy, such as ketamine. Ketamine is an anaesthetic agent with a rapid action that has medical and veterinary applications. Drug users who...
Psychopharmacology
March 1996
J H Kehne, R A Padich, T C McCloskey et al.
Increasing evidence suggests an important role for serotonin (5-HT) neurons in the etiology and treatment of schizophrenia. The prepulse inhibition paradigm is used as a model for sensorimotor gating processes that are disrupted in schizophrenia. The present study assessed the general role of 5-HT in modulating auditory and visual prepulse inhibition in Wistar rats. A general overactivation of...
Psychopharmacology
March 1996
R A Padich, T C McCloskey, J H Kehne
Increasing evidence suggests an important role of 5-HT, and 5-HT2A receptors in particular, in the etiology and treatment of schizophrenia. The prepulse inhibition paradigm is used as a model for sensorimotor gating processes that are disrupted in schizophrenia. The present study used the selective serotonin2A (5-HT2A) antagonist and putative antipsychotic agent MDL 100,907 to evaluate the...
Pharmacology, Biochemistry, and Behavior
January 1996
D Marona-Lewicka, G S Rhee, J E Sprague et al.
The present study was designed to characterize further the rewarding and aversive properties of 3,4-methylenedioxymethamphetamine (MDMA), the alpha-ethyl homologue of MDMA (MBDB), fenfluramine, and the selective serotonin releasing agent 5-methoxy-6-methyl-2-aminoindan (MMAI) using the conditioned place preference paradigm (CPP). Extracellular dopamine (DA) and its metabolite DOPAC were also...
Experiment
1996
Viktor Teider
42 citations
In experimental animals, administration of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy) leads to extensive, but incomplete, loss of 5-hydroxytryptamine (5-HT) innervation in the brain. Here, we report the effects of MDMA on 5-HT neuronal function measured in the rat in vivo using electrophysiological and microdialysis techniques. Two weeks after administration of an established neurotoxic...
Dialogue: A Journal of Mormon Thought
December 1, 1995
Shelby M. Barnes
Frederick Madison Smith was third president and prophet of the Reorganized Church of Jesus Christ of Latter Day Saints.Son of Joseph III and grandson of Joseph the Martyr, Fred M., as he was generally known, came to lead the Reorganization in 1915.Smith was a highly educated man interested in the relationship between science and religion.His interest led him to experiment with the religious...
Journal of Psychopharmacology
May 1, 1995
Hugh Series, Marisa Le Masurier, Sarah E. Gartside et al.
13 citations
The amphetamine derivatives p-chloroamphetamine (pCA), 3,4-methylenedioxymethamphetamine (MDMA, 'Ecstasy') and D-fenfluramine can, if given repeatedly in high doses to rats, produce a degeneration of serotonergic nerve terminals which we have previously shown to result in a reduction in D-fenfluramine-evoked release of 5-HT in vivo. It is therefore possible that fenfluramine-evoked responses...