Benzofurans and benzodifurans are two groups of psychoactive substances that had originally been synthesized for research purpose. Benzofurans' structure is quite similar to the known recreational drug 3,4-methylenedioxymethamphetamine together with its active metabolite 3,4-methylenedioxyamphetamine. Benzodifurans are closely related to phenethylamines, but have more hallucinogens effects and...
The term entheogen refers to drugs—including the artificial substances and active principles drawn from them—which are known to produce ecstasy and have been used traditionally in certain religious and shamanic contexts. The entheogenic experiences provoked by entheogens are described by users in myriad ways, including in spiritual, religious, philosophical, and secular contexts. Entheogenic...
Purpose. The author will show that metaphysical concepts and the concepts of empirical sciences derive from experience. The only difference is that metaphysical concepts derive from unusual experience, i.e. out-of-body experience, while empirical sciences – from usual one. The example set metaphysical concept of pure being. Methodology. In order to obtain this goal the author uses two methods....
The purpose of this study was to compare the effects of mephedrone and 3,4-methylenedioxy-methamphetamine (MDMA), as reported by young recreational polydrug users. 152 MDMA users and 81 mephedrone users were recruited through snowballing on social network sites. They completed a standard online questionnaire for either mephedrone or MDMA. The questions covered the average amount taken per...
Novel psychoactive substances (NPS) are synthetic, psychoactive drugs that are generally not under international regulatory control. NPS are frequently sold as alternatives to classic “street drugs” such as ecstasy or LSD. However, little is known about their pharmacology and toxicity and they therefore pose unknown health risks. Further, risk for harms are elevated because users often do not...
Un être humain est toujours extrêmement en dessous de ce qu'il pourrait être.-HENRI MICHAUX 1 .L 'homme ne saurait se passer de transcendance.Mais depuis que Nietzsche a annoncé la mort de Dieu, une grande partie de l'humanité semble désorientée, en quête d'un substitut qui la console et l'apaise.Les poètes ou les artistes, qu'ils soient ou non athées, ont substitué à ce besoin métaphysique une...
5,6-Methylenedioxy-2-aminoindane (MDAI) has become a common substitute for (±)-3,4-methylenedioxymethamphetamine (MDMA) in Ecstasy. MDAI is known to produce MDMA-like discriminative stimulus effects, but it is not known whether MDAI has psychostimulant or hallucinogen-like effects. MDAI was tested for locomotor stimulant effects in mice and subsequently for discriminative stimulus effects in...
once confided to his secretary at Harvard that he was a schizophrenic. In this article, the author, who is also a schizophrenic, discusses symptoms of schizophrenia in Tillich's biography and theology. Tillich had always insisted that his theology was one of the kairos. By hiding his theological thought behind an arcane Greek word, Tillich dissimulated his own messiah complex. On several...
Recreational use of mephedrone, alone and in combination with alcohol, has increased over the past years. Pharmacological properties of mephedrone share similarities with methylenedioxymethamphetamine (MDMA), but its effect on neurocognitive function has not been well established in humans. The present study assessed the effect of mephedrone alone and after co-administration with alcohol on...
Psychosis can be associated with acute recreational drug and novel psychoactive substance (NPS) toxicity. However, there is limited data available on how common this is and which drugs are most frequently implicated. We describe a European case series of psychosis associated with acute recreational drug toxicity, and estimate the frequency of psychosis for different recreational drugs. The...