Clinical Pharmacology & Therapeutics
January 13, 2017
Marilyn A. Huestis, Rachel F. Tyndale
12 citations
This “Designer Drugs 2.0” issue of Clinical Pharmacology & Therapeutics focuses on novel psychoactive substances, primarily cannabinoids and cathinones, and the repurposing of established psychoactive compounds (e.g., modafinil, psilocybin, lysergic acid diethylamide, and 3,4‐methylenedioxymethamphetamine) that simultaneously offer new pharmacotherapies and pose serious health problems. Novel...
Current Topics in Behavioral Neurosciences
2017
Linda D. Simmler, Matthias E. Liechti
Pharmacological assays carried out in transfected cells have been very useful for describing the mechanism of action of cathinone new psychoactive substances (NPS). These in vitro characterizations provide fast and reliable information on psychoactive substances soon after they emerge for recreational use. Well-investigated comparator compounds, such as methamphetamine,...
Current Pharmaceutical Design
2017
Bernardino Barcelo, Isabel Gomila
Benzofurans and benzodifurans are two groups of psychoactive substances that had originally been synthesized for research purpose. Benzofurans' structure is quite similar to the known recreational drug 3,4-methylenedioxymethamphetamine together with its active metabolite 3,4-methylenedioxyamphetamine. Benzodifurans are closely related to phenethylamines, but have more hallucinogens effects and...
2017
Joshua Falcon
The term entheogen refers to drugs—including the artificial substances and active principles drawn from them—which are known to produce ecstasy and have been used traditionally in certain religious and shamanic contexts. The entheogenic experiences provoked by entheogens are described by users in myriad ways, including in spiritual, religious, philosophical, and secular contexts. Entheogenic...
Anthropological Measurements of Philosophical Research
December 21, 2016
I. V. Karivets
Purpose. The author will show that metaphysical concepts and the concepts of empirical sciences derive from experience. The only difference is that metaphysical concepts derive from unusual experience, i.e. out-of-body experience, while empirical sciences – from usual one. The example set metaphysical concept of pure being. Methodology. In order to obtain this goal the author uses two methods....
Journal of Psychopharmacology
December 2016
Lewis Jones, Phil Reed, Andrew C. Parrott
The purpose of this study was to compare the effects of mephedrone and 3,4-methylenedioxy-methamphetamine (MDMA), as reported by young recreational polydrug users. 152 MDMA users and 81 mephedrone users were recruited through snowballing on social network sites. They completed a standard online questionnaire for either mephedrone or MDMA. The questions covered the average amount taken per...
Clinical pharmacology and therapy
November 29, 2016
Zr Patterson, M. Scott Young, F. Vaccarino
15 citations
Novel psychoactive substances (NPS) are synthetic, psychoactive drugs that are generally not under international regulatory control. NPS are frequently sold as alternatives to classic “street drugs” such as ecstasy or LSD. However, little is known about their pharmacology and toxicity and they therefore pose unknown health risks. Further, risk for harms are elevated because users often do not...
Otrante.
November 1, 2016
Lucien d’Azay
Un être humain est toujours extrêmement en dessous de ce qu'il pourrait être.-HENRI MICHAUX 1 .L 'homme ne saurait se passer de transcendance.Mais depuis que Nietzsche a annoncé la mort de Dieu, une grande partie de l'humanité semble désorientée, en quête d'un substitut qui la console et l'apaise.Les poètes ou les artistes, qu'ils soient ou non athées, ont substitué à ce besoin métaphysique une...
Behavioural Pharmacology
September 2016
Michael B. Gatch, Sean B. Dolan, Michael J Forster
5,6-Methylenedioxy-2-aminoindane (MDAI) has become a common substitute for (±)-3,4-methylenedioxymethamphetamine (MDMA) in Ecstasy. MDAI is known to produce MDMA-like discriminative stimulus effects, but it is not known whether MDAI has psychostimulant or hallucinogen-like effects. MDAI was tested for locomotor stimulant effects in mice and subsequently for discriminative stimulus effects in...
Journal of literature and art studies
August 30, 2016
R. Dole
once confided to his secretary at Harvard that he was a schizophrenic. In this article, the author, who is also a schizophrenic, discusses symptoms of schizophrenia in Tillich's biography and theology. Tillich had always insisted that his theology was one of the kairos. By hiding his theological thought behind an arcane Greek word, Tillich dissimulated his own messiah complex. On several...