Pharmacology, Biochemistry, and Behavior
January 1981
T Yamamoto, S Ueki
Head-twitch induced by lysergic acid diethylamide, mescaline and 2,5-dimethoxy-4-methylamphetamine (DOM) was significantly increased by medial raphe (m-R) lesions, but dorsal raphe (d-R) lesions did not produce any changes. Hallucinogen-induced head twitch was inhibited by methysergide and tended to be increased by PCPA. These results suggest that 5-HT receptors innervated with the ascending...
Pharmacology, Biochemistry, and Behavior
October 1980
Torbjörn U C Järbe
Pigeons (N=4) were trained to discriminate between the effects induced by intramuscular (IM) injections of d-LSD and saline using a discrete-trial discrimination paradigm (choice between left and right hand key) in a conventional operant box. The solutions were administered IM 15 min prior to the sessions. A FR 15 schedule was in operation to produce food. Which of the two keys was correct on a...
OMEGA - Journal of Death and Dying
February 1, 1980
William A. Richards, John Rhead, Stanislav Grof et al.
20 citations
Thirty cancer patients suffering from psychological distress participated in a pilot project of individual psychotherapy that offered – over a four week period of time – approximately twelve hours of conventional verbal interaction and a single intensive drug-assisted therapy session that employed dipropyltryptamine (DPT), a short-acting psychedelic drug. The efficacy of the total therapeutic...
Psychopharmacology
1980
H E Shannon
3,4-Methylenedioxyamphetamine (MDA) and 2,5-dimethoxy-4-methylamphetamine (DOM) are amphetamine congeners that produce both amphetamine-like and LSD-like effects. To evaluate whether MDA and DOM should be classed with amphetamine, their capacity to produce amphetamine-like discriminative stimuli was assessed. Rats were trained to discriminate between saline and 1.0 mg/kg d-amphetamine in a two...
Psychopharmacology
1980
E B Nielsen, T H Lee, G Ellison
Rats injected with LSD or mescaline show the behavioral syndrome which has been previously reported following injections of hallucinogens in higher mammals: limb flicks and whole body shakes. Although these behaviors are not elicited by acute injections of amphetamine, they are present in rats which have been pretreated for 108 h with a slow-release amphetamine pellet, given a 12 h rest period,...
Pharmacology, Biochemistry, and Behavior
January 1980
Matthew Fairchild, Donald J. Jenden, M R Mickey et al.
Three hallucinogens (d-lysergicacid diethylamide (LSD), mescaline, psilocybin) and two cannabinoid derivatives (tetrahydrocannabinol (THC), synhexyl) were tested for their long-term effects on the EEG of the cat. The drug-induced alterations in the EEG frequency spectrum were "drug-specific" in the sense that they would be statistically unlikely to occur during sleep-waking behavior. The two...
Pharmacology, Biochemistry, and Behavior
November 1979
Heidrun Fink, R Morgenstern, Wolfgang Oelssner
The spontaneous locomotor activity of rats was investigated in an open-field test. Apomorphine and d,1-amphetamine caused a dose dependent increase of locomotor activity. LSD, mescaline, and DMT in low doses were ineffective, when given alone, but caused a strong potentiation of the hypermotility induced by apomorphine and d,1-amphetamine. Cyproheptadine antagonized the potentiating effect of...
Psychopharmacology
September 1979
Mark A. Geyer, Roger K. Light, Gary J. Rose et al.
The disruption of the temporal distribution of investigatory responses by rats in a novel hole-board following lysergic acid diethylamide-25 (LSD), as described in a companion paper (Geyer and Light, 1979), was found to be a characteristic effect of a variety of hallucinogens. Similar effects were produced by indoleamine hallucinogens, such as LSD, N,N-dimethyltryptamine, and psilocin, and by...
BMJ
May 19, 1979
F. van Knapen, J.h. Franchimont, G M Otter
21 citations
The law was subsequently changed to make possession of the plant illegal.Thus unless the Act is amended to name the psilocybin mushroom possession is legal.Apparently increasing numbers of teenagers and others are harvesting and eating the mushrooms.2Doctors should therefore be aware of possible long-term side effects of such agents.One of these is the flashback phenomenon described by about 5%...
British Journal of Pharmacology
April 1, 1979
Martin Graf, A. Pletscher
45 citations
In blood platelets of rabbits isolated by a stractan gradient and incubated in a protein‐poor medium, tryptamine, 5‐hydroxytryptamine (5‐HT) and derivatives, quipazine and mescaline caused a shape change. This shape change was inhibited by low concentrations of methysergide. The most potent antagonists of the 5‐HT‐induced shape change included ergoline derivatives and neuroleptic drugs, which...