Substance Use & Misuse
2025
Torbjørn Lien Kjær, Peter Hindersson, Jacob Rong Bentzen et al.
2 citations
Drug use in Danish prisons has previously not been investigated in detail using confirmatory, laboratory analysis. The objective of the present quality study, initiated by the Danish Prison and Probation Service, was to i) evaluate the performance of an initial, on-site drug screening strategy; ii) gain insights into emerging drug trends; and iii) suggest evidence-based strategies for future...
Journal of Medical Toxicology
2025
Caitlin E Wolfe, Lachlan J Sund, John Rh Archer et al.
5 citations
Novel Psychoactive Substance (NPS) use is increasingly prevalent and is often associated with severe acute recreational drug toxicity (ARDT). 258 UK deaths were attributed to NPS use in 2021. Confirmatory testing which identifies NPS is limited by expense and timeliness. We aimed to identify NPS and other recreational drugs in a sample of 1000 ARDT presentations to a central London hospital in...
The Science of the total environment
2025
Marija Stevanović, Niki Tagkalidou, Cristiana Roberta Multisanti et al.
15 citations
The acoustic startle response (ASR) is leaded by a sudden and intense acoustic stimulus. ASR has several forms of plasticity, including habituation and sensorimotor gating. Although ASR and its plasticity have been intensively studied in zebrafish (Danio rerio) larvae, information in adult zebrafish is still very scarce. In this manuscript we present Zebra_K, a new automated high-content...
Veterinary anaesthesia and analgesia
2025
Monica Midon, Stuart C Clark-Price, Hui-Chu Lin et al.
To determine if serum iron concentrations decrease acutely during and after general anesthesia in healthy horses. Prospective experimental study. A convenience sample of 24 healthy adult horses (eight females, 16 geldings), weighing 545 ± 33 kg (mean ± standard deviation). Horses were anesthetized for 120 minutes with isoflurane, after premedication with intravenous (IV) xylazine (0.8 mg kg-1)...
Critical care science
2025
Jariya Sereeyotin, Christopher Yarnell, Sangeeta Mehta
5 citations
This study aimed to compare sedation management during and after intubation in the emergency department with that in the intensive care unit. This was a single-center retrospective cohort study of adults who were intubated in the emergency department or intensive care unit and who received mechanical ventilation between January 2018 and February 2022. We collected data from electronic medical...
PLoS One
2025
Sarah Kratina, Carol Strike, Robert Schwartz et al.
1 citation
Psychedelic substances are increasingly recognized for their therapeutic potential to ease psychological suffering linked to end-of-life issues. However, amid renewed scientific and public interest, policy remains restrictive. Existing reviews have made progress in synthesizing the results of studies of psychedelic interventions, especially psilocybin, and particularly with regard to their...
Revista Brasileira de Farmácia Hospitalar e Serviços de Saúde
December 26, 2024
Gabriela Ribeiro Pena, Fernando Henrique Teixeira Zonzini, Aline de Fátima Bonetti
1 citation
Objetivo: Analisar as evidências relacionadas a eficácia e a segurança da cetamina intravenosa para o tratamento de pacientes adultos com transtorno unipolar depressivo maior refratário a tratamentos prévios. Metodologia: Trata-se de uma overview de revisões sistemáticas realizada conforme o check-list PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) e as...
Journal of Psychopharmacology
December 10, 2024
Mattia Marchi, Riccardo Farina, Karim Rachedi et al.
13 citations
Background: The interest in psychedelics as a therapeutic intervention for existential distress of people with terminal illness grounds on their mechanism of action and effect on the spiritual/existential aspects accompanying end-of-life experiences. Aims: This systematic review and network meta-analysis aimed at examining the efficacy and safety of psychedelic compounds for existential...
International Journal of Psychology
December 6, 2024
Monica Schweickle, Ted Cassidy
Purpose: The goal of this case report is to illustrate the implementation of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for posttraumatic stress disorder (PTSD) and learning points for health professionals in the translation of psychedelic assisted therapy research into clinical practice. We present our key learnings and 6-month follow up data from one of the first patients to...
Molecular Psychiatry
December 1, 2024
Chloe E Page, C Neill Epperson, Andrew M Novick et al.
54 citations
The serotonin deficit hypothesis explanation for major depressive disorder (MDD) has persisted among clinicians and the general public alike despite insufficient supporting evidence. To combat rising mental health crises and eroding public trust in science and medicine, researchers and clinicians must be able to communicate to patients and the public an updated framework of MDD: one that is (1)...