Frontiers in Neuroscience
July 21, 2015
Lisa Scheuing, Chi‐Tso Chiu, Hsiao‐Mei Liao et al.
65 citations
A debilitating mental disorder, major depressive disorder is a leading cause of global disease burden. Existing antidepressant drugs are not adequate for the majority of depressed patients, and large clinical studies have demonstrated their limited efficacy and slow response onset. Growing evidence of low-dose ketamine's rapid and potent antidepressant effects offers strong potential for future...
Indian Journal of Pharmacology
July 1, 2015
Girish H. Banwari, Prutha B Desai, P. Patidar
There is growing evidence to support the rapid, albeit short-lived antidepressant effect of subanesthetic dose of ketamine, a noncompetitive glutamate N-methyl-D-aspartate receptor antagonist in treatment-resistant unipolar and bipolar depression. Ketamine is known to cause transient mood elevation or euphoria, psychotomimetic effects, and dissociative symptoms, but its use in unipolar or...
Proceedings of the National Academy of Sciences
June 8, 2015
Manabu Fuchikami, Alexandra M. Thomas, Rongjian Liu et al.
282 citations
Ketamine produces rapid and sustained antidepressant actions in depressed patients, but the precise cellular mechanisms underlying these effects have not been identified. Here we determined if modulation of neuronal activity in the infralimbic prefrontal cortex (IL-PFC) underlies the antidepressant and anxiolytic actions of ketamine. We found that neuronal inactivation of the IL-PFC completely...
European Psychiatry
June 1, 2015
G.-F. Zhang, W.-X. Liu, L.-L. Qiu et al.
Abstract: Current available antidepressants exhibit low remission rate with a long response lag time. Growing evidence has demonstrated acute sub-anesthetic dose of ketamine exerts rapid, robust, and lasting antidepressant effects. However, a long term use of ketamine tends to elicit its adverse reactions. The present study aimed to investigate the antidepressant-like effects of intermittent...
Shanghai archives of psychiatry
June 1, 2015
Ni Fan, Ke Xu, Yuping Ning et al.
Background: Ketamine is an increasingly popular drug of abuse in China but there is currently no method for classifying the psychological effects of ketamine in individuals with ketamine dependence. Aim: Develop a scale that characterizes the acute and long-term psychological effects of ketamine use among persons with ketamine dependence. Methods: We developed a preliminary symptom checklist...
Pharmacology, Biochemistry, and Behavior
June 1, 2015
Chrislean Jun Botanas, J. B. de la Peña, I. J. D. Dela Peña et al.
Methoxetamine (MXE) is an N-methyl-d-aspartate (NMDA) receptor antagonist that is chemically and pharmacologically similar to ketamine. Recently, there have been many reports regarding its use/misuse in humans which have resulted in serious or even fatal outcomes. Despite these reports, MXE is not controlled or regulated in many countries which may be partly due to the lack of scientific...
Psikiyatride Güncel Yaklaşımlar
May 31, 2015
Feride Karacaer
Standart antidepressants are needed for the many individuals with major depressive disorder. However they do not respond adequately to treatment and because of a delay of weeks before the emergence of therapeutic effects. Recent studies show that subanesthetic dose of ketamine is efficacy and safety for the treatment of depression. Antidepressant effects of ketamine have been found to be...
Psychopharmacology
May 20, 2015
J. Jett, Angela M. Boley, M. Girotti et al.
Acute low-dose administration of the N-methyl-D-aspartate (NMDA) receptor antagonist, ketamine, produces rapid and sustained antidepressant-like effects in humans and rodents. Recently, we found that the long-lasting effect of ketamine on the forced swim test requires ventral hippocampal (vHipp) activity at the time of drug administration. The medial prefrontal cortex (mPFC), a target of the...
Psychopharmacology
May 19, 2015
R. Joules, O. Doyle, A. J. Schwarz et al.
77 citations
Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, has been studied in relation to the glutamate hypothesis of schizophrenia and increases dissociation, positive and negative symptom ratings. Ketamine effects brain function through changes in brain activity; these activity patterns can be modulated by pre-treatment of compounds known to attenuate the effects of ketamine on glutamate...
May 6, 2015
S. Best
Treatment resistant depression (TRD) is a major public health issue, with comorbid OCD contributing to the general medical costs and severity associated with TRD. Recent research has investigated the efficacy of transcranial magnetic stimulation (TMS and its variant rTMS) in ameliorating the symptoms of depression and OCD. Most studies have used TMS to facilitate electromagnetic stimulation of...