Ketamine for PTSD: all studies (page 7) - The Consciousness Library

Rapid and sustained reduction of treatment-resistant PTSD symptoms after intravenous ketamine in a real-world, psychedelic paradigm.

Journal of Psychopharmacology 2025 Henry A MacConnel, Mitch Earleywine, Steven Radowitz 5 citations

Traditional treatments for post-traumatic stress disorder (PTSD) often show limited success with high dropout. Ketamine, an N-methyl-D-aspartate antagonist known for rapid antidepressant effects, has decreased PTSD symptoms in some studies but not in others. Administering ketamine in ways that parallel psychedelic-assisted treatments-including preparatory, integration, sensory immersion, and...

DOI: 10.1177/02698811241286726 Full text PTSD Ketamine-assisted psychotherapy Psychedelic Kap +1

Efficacy of fluoxetine and (R,S)-ketamine in attenuating conditioned fear behaviors in male mice.

Journal of Pharmacology and Experimental Therapeutics 2025 Megan Wells, Jan Hoffmann, Autumn Stage et al. 1 citation

Post-traumatic stress disorder (PTSD) is caused by exposure to a traumatic or stressful event. Symptoms related to this disorder include persistent re-experiencing of memories and fear of generalization. Current pharmacological treatments for PTSD are insufficient, with fewer than 30% of patients reporting symptom remission. This study aims to determine the efficacy of acute (R,S)-ketamine and...

DOI: 10.1124/jpet.124.002252 Full text Ketamine Post-traumatic stress disorder Conditioned fear Fluoxetine +7

Biological treatments for co-occurring eating disorders and psychological trauma: a systematic review.

Frontiers in Psychiatry 2025 Ella van Beers, Irene de Vries, Caroline Planting et al. 2 citations

Many people with eating disorders report having experienced childhood maltreatment or a traumatic event prior to developing an eating disorder. Although many people with eating disorders have significant traumatic exposure or symptoms of post-traumatic stress disorder, very little research has examined the effects of combined treatments for this group. The purpose of this systematic review was...

DOI: 10.3389/fpsyt.2025.1523269 Full text MDMA Post-traumatic stress disorder Bulimia nervosa Binge eating disorder +6

Case Report: Successful management of psychogenic non-epileptic seizures with intranasal esketamine.

Frontiers in Psychiatry 2025 Muneeb Hashmi, Padmasini Mugunthan, Priyal Jain et al. 2 citations

Psychogenic non-epileptic seizures (PNES), or functional seizures (FS), are episodes that resemble epileptic seizures but may be psychological in origin. Unlike epileptic seizures, which are linked to abnormal electrical activity in the brain, functional seizures may be associated with psychological and/or physical distress, and do not show the same electrical patterns on an...

DOI: 10.3389/fpsyt.2025.1527166 Full text Anxiety Esketamine Post-traumatic stress disorder Functional seizures +7

Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report.

Journal of Medical Case Reports December 24, 2024 S Asad, K Latifzai, V T Eliopoulos et al. 1 citation

Ketamine treatment presents a novel approach for addressing refractory conditions, such as major depressive disorder, suicidal ideation, and posttraumatic stress disorder, which often co-occur and pose significant challenges for clinicians. This study explores the clinical and electrophysiological outcomes of ketamine treatment in two cases, shedding light on its potential efficacy and...

DOI: 10.1186/s13256-024-04972-8 Full text Major depressive disorder Case report Electroencephalogram Ketamine therapy +4

(2R,6R)-hydroxynorketamine alleviates PTSD-like endophenotypes by regulating the PI3K/AKT signaling pathway in rats.

Pharmacology, Biochemistry, and Behavior December 1, 2024 Lifen Liu, Rui Li, Lanxia Wu et al. 3 citations

Patients diagnosed with post-traumatic stress disorder (PTSD) mainly exhibit enduring adverse emotions, heightening susceptibility to suicidal thoughts and behaviors. Notably, metabolites of ketamine, particularly (2R,6R)-hydroxyketamine (HNK), have demonstrated favorable antidepressant properties. However, the precise mechanism through which HNK exerts its therapeutic effects on negative...

DOI: 10.1016/j.pbb.2024.173891 Full text Post-traumatic stress disorder 2r,6r-hnk Negative emotions Pi3k/akt signaling pathway +4

Low dose oral ketamine treatment on post-traumatic stress disorder (PTSD) (OKTOP): An open-label pilot study

medRxiv Preprint Server November 26, 2024 Bonnie L. Quigley, Adem T. Can, Megan Dutton et al. 1 citation preprint

Ketamine is being actively investigated as a rapid-acting treatment for many conditions with a stress-related psychopathology, including post-traumatic stress disorder (PTSD). The majority of studies regarding ketamine treatment for PTSD to date (including open-label and randomised control trials) have focused on intravenous (IV) ketamine administration. This administration route has...

DOI: 10.1101/2024.11.26.24318024 Full text Low-dose oral ketamine PTSD Treatment PTSD Therapy PTSD Relief +8

Ketamine alleviates PTSD-like effect and improves hippocampal synaptic plasticity via regulation of GSK-3β/GR signaling of rats.

Journal of Psychiatric Research October 1, 2024 Zixun Wang, Xinyu Hu, Zhongyi Wang et al. 9 citations

Each year, 3-4% of the global population experiences post-traumatic stress disorder (PTSD), a chronic mental disorder with significant social and economic repercussions. Although it has been shown that ketamine can effectively alleviate PTSD symptoms in individuals, the specific mechanism of action underlying its anti-PTSD effects remains unclear. In this study, we investigated how a single,...

DOI: 10.1016/j.jpsychires.2024.08.019 Full text Synaptic plasticity Gr Gsk-3β Ketamine therapy +3

Ketamine ameliorates post-traumatic social avoidance by erasing the traumatic memory encoded in VTA-innervated BLA engram cells.

Neuron September 25, 2024 Ming Li, Xue-Ke Yang, Jian Yang et al. 30 citations

Erasing traumatic memory during memory reconsolidation is a promising retrieval-extinction strategy for post-traumatic stress disorder (PTSD). Here, we developed an acute social defeat stress (SDS) mouse model with short-term and re-exposure-evoked long-term social avoidance. SDS-associated traumatic memories were identified to be stored in basolateral amygdala (BLA) engram cells. A single...

DOI: 10.1016/j.neuron.2024.06.026 Full text Post-traumatic stress disorder Basolateral amygdala Dopamine d2 receptor Memory engram cells +7

Psychedelics: A review of their effects on recalled aversive memories and fear/anxiety expression in rodents

Neuroscience & Biobehavioral Reviews September 20, 2024 Isabel Werle, Leandro J Bertoglio 17 citations

Threatening events and stressful experiences can lead to maladaptive memories and related behaviors. Existing treatments often fail to address these issues linked to anxiety/stress-related disorders effectively. This review identifies dose ranges associated with specific actions across various psychedelics. We examined psilocybin/psilocin, lysergic acid diethylamide (LSD),...

DOI: 10.1016/j.neubiorev.2024.105899 Ayahuasca Ecstasy Ibogaine Ketamine +7