Acute oral 18-methoxycoronaridine (18-MC) decreases both alcohol intake and IV nicotine self-administration in rats.
Pharmacology, Biochemistry, and Behavior 2016 Amir H Rezvani, Marty C Cauley, Susan Slade et al. 22 citations
The ibogaine derivative 18-methoxycoronaridine (18-MC) has been found to decrease self-administration of morphine, nicotine and alcohol in rats after systemic injection. However oral dosing is the preferred route clinically. The current study evaluated the effect of oral 18-MC dosing in rats on alcohol and nicotine self-administration. For the nicotine study, young adult female Sprague-Dawley...
DOI: 10.1016/j.pbb.2016.10.010 (opens in new tab)
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Alcohol preferring rat
Drinking
Addiction treatment
Alcoholism research
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