Journal of PsychopharmacologyOctober 4, 2025Michael G. Palfreyman, Geoffrey B. Varty, Erik M. Stang et al.3 citations
The last decade represented a period of unprecedented interest in, and development of, traditional psychedelic substances for the treatment of a variety of neuropsychiatric disorders. While early clinical trials of classical psychedelics, several of the major ones being tryptamines, have demonstrated robust efficacy in patients with minimal adverse effects, many of these molecules have...
After years of restrictions due to concerns about their potentially harmful effects, research on psychedelics has entered a new era. Increasing attention has been directed toward their immense therapeutic potential, particularly for psychiatric disorders. Pre-clinical and clinical studies have consistently demonstrated that psychedelic treatments produce therapeutic effects within hours of...
Psychedelics have a profound potential to catalyze psychological transformation and support traditional cultures and ways of life. However, many naturally occurring psychoactive plants and animals are facing threats from climate change, habitat loss and other anthropogenic pressures like overharvesting. In this narrative review we examine the conservation issues pertaining to some of the most...
Psychedelics are undergoing a clinical research renaissance, with compounds such as psilocybin advancing to Phase 3 trials for treatment-resistant depression and receiving fast-track or breakthrough designations from regulatory agencies. Despite this progress, the field lacks standardized terminology to guide clinical development, dosing, safety monitoring, and regulatory classification. Here,...
A revolutionary change in contemporary therapeutic paradigms may be seen in the renewed interest in psychedelic plant remedies. Psychedelic plants like psilocybe mushrooms, ayahuasca, iboga, and salvia divinorum, which have long been valued for their spiritual and therapeutic qualities in a variety of cultures, are now the subject of intense scientific research. According to recent clinical...
Drugs AgingJune 24, 2025Lou Vinarcsik, Charles Smoller, George Grossberg1 citation
The use of drugs with psychedelic and dissociative effects for the treatment of psychiatric illnesses has become increasingly popular in recent years. However, few trials have been conducted to determine the efficacy of these agents in the specific setting of treatment-resistant major depressive disorder (MDD) in older adults. In this paper, we review notable aspects of treatment-resistant MDD...
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N , N ‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g. ibogaine, ketamine and esketamine; and other atypicals e.g. dextromorphan/bupropion, esmethadone....
Plants can generate structural diversity by enzymatic rearrangement of a central intermediate. 19E-geissoschizine is one such chemically versatile intermediate that plays a central role in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Here we report how 19E-geissoschizine undergoes oxidative transformations to generate four distinct alkaloid...
May 1, 2025Eve E. Keighley, Dalia A Bedewy, Eid Abo Hamza et al.1 citation
preprint
Given the recent resurgence of using psychedelic drugs to treat substance misuse (SM), reviewing the latest information on their current status is essential. Substance use disorders (SUD) are psychiatric conditions that comprise the repetitive use of illicit substances, despite the harmful and damaging ramifications. Current treatment options for SUD are limited and have displayed low...
Background and Objectives: Substance use disorders (SUDs) affect millions worldwide. Despite increasing drug use, treatment options remain limited. Psychedelic-assisted therapy (PAT), integrating psychedelic substances with psychotherapy, offers a promising alternative by addressing underlying neural mechanisms. Materials and Methods: This review’s purpose is to investigate the current...