Oxidative Rearrangements of the Alkaloid Intermediate Geissoschizine.
Angewandte Chemie (International ed. in English) June 10, 2025 Mohamed O. Kamileen, Benke Hong, Klaus Gase et al. 11 citations
Plants can generate structural diversity by enzymatic rearrangement of a central intermediate. 19E-geissoschizine is one such chemically versatile intermediate that plays a central role in the biosynthesis of monoterpene indole alkaloids such as strychnine, ibogaine, and vinblastine. Here we report how 19E-geissoschizine undergoes oxidative transformations to generate four distinct alkaloid...