Recent trends in social research indicate a decline in church attendance and a corresponding increased interest in spirituality. With the aging of the population, attention to end of life care, with its corresponding spiritual concerns and distress, has become a prominent issue. Spiritual distress can be difficult to distinguish from psychological and physical distress and indicates the need...
To review the pharmacology, therapeutics, adverse effects, and societal implications of the medical use of marijuana. MEDLINE and manual searches of English-language marijuana literature, supplemented with interviews of scientists currently conducting cannabinoid research. Search terms included pain OR palliative care AND cannabis or ALL marijuana; cachexia OR appetite OR appetite stimulants;...
This study examined the dreams of eight individuals admitted to the Palliative Care Unit of the Elisabeth Bruyere Health Centre, Ottawa, Canada. Content analysis of the dream reports in this sample supports the hypothesis that a continuity exists between dreaming and waking experience [1]. Results do not indicate that themes of death and aggression, negative emotion, or infant and child...
The purpose of this article is to explicate the development of an emerging middle-range nursing theory of self-transcendence. The process of developing the theory was based largely on the method of "deductive reformulation." Using this strategy, theoretic knowledge derived from life span developmental psychology was reformulated based on Rogers' conceptual system. Clinical experience and...
(1970). Psychedelic Therapy (Utilizing LSD) with Cancer Patients. Journal of Psychedelic Drugs: Vol. 3, LSD. The Psychedelic Experience and Beyond, pp. 63-75.
Background: Patients with ALS commonly exhibit pseudobulbar affect. Methods: The authors conducted a multicenter, randomized, double-blind, controlled, parallel, three-arm study to test a defined combination of dextromethorphan hydrobromide (DM) and quinidine sulfate (Q) (AVP-923) for the treatment of pseudobulbar affect in ALS. Q inhibits the rapid first-pass metabolism of DM. The effects of...
There has been resurgence of interest in the therapeutic use of serotonergic ("classic") psychedelics in major depressive disorder (MDD) and end-of-life distress. This commentary offers a critical appraisal of current evidence for antidepressant effects of classic psychedelics from contemporary clinical trials and highlights pitfalls that should be addressed before clinical translation. A...
Clinical NeuropharmacologyRamiro Manzano-Nunez, Diego A Gomez, Catalina Toledo-Mendoza et al.3 citations
This scoping review aimed to synthesize the existing data about psilocybin pharmacokinetics to learn what has been described regarding body disposition and safety when psilocybin was used in controlled research settings. We performed a scoping literature review following the framework proposed by the JBI manual for evidence synthesis. Controlled clinical trials reporting pharmacokinetic data of...
Legal access to psilocybin almost always requires a medical diagnosis first, usually treatment-resistant depression (TRD) or severe PTSD, as though informed consent alone was not sufficient. This article makes two connected arguments. Extending the autonomy argument already accepted for terminally ill patients, competent adults who understand the potential benefits and risks of a psilocybin...