Frontiers in Psychology
2026
Human-Friedrich Unterrainer
Altered states of consciousness range from psychotic disintegration to mystical union, with oceanic affectivity - experiences of ego dissolution, boundlessness, and affective merging - constituting a central feature. While such states can be induced by psychedelics, they also occur through trauma, meditative practices, or within compulsive addictive cycles. In addition, oceanic states may offer...
Neuroscience of Consciousness
2026
Ronald Sladky
Current theories of consciousness often emphasize its ego-centric functions, highlighting the role of the insular cortex in interoceptive self-modeling and subcortical brain regions in qualitative experience and motivation, aptly described as the 'hidden spring' of consciousness. From ecological and pragmatic perspectives, conscious experience may facilitate the self-organization of complex...
General Hospital Psychiatry
2026
Rebeca Cohen, João Bastos, Catarina Cunha et al.
1 citation
Ketamine, an N-methyl-d-aspartate antagonist, shows promise for treatment-resistant depression (TRD), with psychedelic doses potentially enhancing efficacy. However, its transient antidepressant effects and the need for repeated infusions raise concerns about optimal duration and long-term safety. Two clinical trials have tested the combination of ketamine with psychotherapy for depression,...
Journal of Neuroscience
November 24, 2025
Mona Irrmischer, Marco Aqil, Lisa Luan et al.
Psychedelics profoundly alter subjective experience and brain dynamics. Brain oscillations express signatures of near-critical dynamics, relevant for healthy function. Alterations in the proximity to criticality have been suggested to underlie the experiential and neurological effects of psychedelics. Here, we investigate the effects of a psychedelic substance (DMT) on the criticality of brain...
Scientific Reports
November 6, 2025
Anna O. Ermakova, Fiona Dunbar, Mathieu Seynaeve et al.
3 citations
5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a naturally occurring psychedelic tryptamine. Plants containing 5-MeO-DMT have been used throughout history, and in recent years both synthetic and toad-derived 5-MeO-DMT use is being increasingly reported in naturalistic settings as well as clinical research. However, its subjective effects are not well characterised, and no qualitative research...
Neuroimage
June 1, 2025
Dila Suay, Helena Aicher, Micheal Kometer et al.
4 citations
Psychedelics are known to profoundly alter perception and self-referential processing, yet their specific effects on face recognition -particularly with regard to the recognition of face familiarity-remain underexplored. This study investigates the effects of an ayahuasca-inspired novel DMT/HAR (N,N-dimethyltryptamine/Harmine) formulation and Harmine alone on face recognition and...
Psychopharmacology
April 23, 2025
Jonathan David, Aviva Berkovich-Ohana, Yair Dor-Ziderman
2 citations
The human psyche's interaction with death fundamentally shapes cognition, emotions, and behavior in both individuals and society. Death-related psychological phenomena have been shown to be influenced by psychedelic interventions. However, the literature lacks a comprehensive assessment of death-related processes in non-clinical settings, the mechanisms underlying long-term changes, and...
Imaging Neuroscience
April 16, 2025
Lorenzo Pasquini, Alexander J. Simon, Courtney L. Gallen et al.
4 citations
Abstract N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory distortions and visual imagery. Multimodal neuroimaging data paired with dynamic analysis techniques offer a valuable approach for identifying...
Current Opinion in Psychology
April 1, 2025
Matthias Forstmann, Christina Sagioglou
11 citations
Recent research suggests that serotonergic psychedelics may simultaneously enhance connectedness to both social and natural worlds. This article synthesizes current evidence regarding psychedelics' effects on nature relatedness and social connectedness, examining underlying mechanisms through the framework of self-other overlap. Psychedelics appear to facilitate self-expansion through two...
Open Theology
February 2, 2025
Sariyar Murat
Deleuze’s philosophy, celebrated for its affirmation of life, also offers a profound and nuanced exploration of death, challenging conventional understandings of individuality and existence. Through key concepts such as the “death drive,” the “virtual,” and “assemblage,” Deleuze frames death not as a terminus, but as an integral process within life itself. This article critically examines...