Depression is one of the leading causes of disability not only in the US but worldwide as well. It is ranked third for global disease burden by the WHO and estimated to affect 350 million people worldwide. The economic burden of depression is estimated to have increased by 21.5% from 2005 to 2010 (from $173.2 billion to $210.5 billion).
Psychedelic drugs, such as lysergic acid diethylamide (LSD), mescaline, and psilocybin, exert profound effects on brain and behavior. After decades of difficulties in studying these compounds, psychedelics are again being tested as potential treatments for intractable biomedical disorders. Preclinical research of psychedelics complements human neuroimaging studies and pilot clinical trials,...
Recently, the N-methyl-d-aspartate-receptor (NMDAR) antagonist ketamine has emerged as a fast-onset mechanism to achieve antidepressant activity, whereas its psychomimetic, dissociative and amnestic effects have been well documented to pharmacologically model schizophrenia features in rodents. Sleep-wake architecture, neuronal oscillations and network connectivity are key mechanisms supporting...
An eighteen years old female patient of the Caucasian ethnicity from New Zealand, she presented with a persistently dilated pupil causing her discomfort and occasional burning sensation when outdoor due to an oversensitivity to sunlight. However, her pupillary reaction to light (pupillary light reflex) was intact. The patient is a known user of psychedelic substances (entheogens) including LSD,...
September 12, 2017Shirlene Aparecida Lopes1 citation
\n Introdução: Fatores que levam a queixas musculoesqueléticas entre profissionais de enfermagem tem sido objeto de várias pesquisas científicas, apontando a necessidade de estratégias no ambiente de trabalho, que promovam saúde para minimizar este cenário emergente. Os programas baseadas em mindfulness - atenção plena - tem demonstrado resultados promissores em aspectos clínicos e não clínicos...
InTech eBooksSeptember 6, 2017Shawn Wu, Lin Hua Jiang, J. Wang
Recently, much more mind-body/mindfulness interventions have been used in different people including frail elders, patients with major depressive order, pain suffering, chronic fatigue, infection, and patients in intensive care unit, etc. In the field of Complementary and Alternative Medicine, many Chinese mind-body exercises are under very active investigation for evidence-based decision...
Down through the ages, people have suspected that dreams and emotional symptoms, phobias, anxiety, depression, obsessions, problems in relating to others, psychologically founded physical ailments, and so forth, are in some way linked. Many ancient cultures practiced dream incubation rituals for healing purposes, attempting to cultivate dreams that would address the reasons for inexplicable...
Caring for a relative with dementia is extremely challenging; conventional interventions may not be highly effective or easily available on some occasions. This study aimed to explore the efficacy of mindfulness training in improving stress-related outcomes in family caregivers of people with dementia using a meta-analytic review. We searched randomized controlled trials (RCT) through April...
While few treatment options exist for low sexual desire and arousal, the most common sexual dysfunction in women, a growing body of research supports the efficacy of mindfulness-based approaches. The mechanisms underlying improvements, and whether they are due to mindfulness practice or other treatment components, are unclear. As a result, we designed and pilot-tested an eight-session group...
A significant number of obsessive-compulsive disorder (OCD) patients continue to experience symptoms that interfere with their functioning following cognitive behavioural therapy (CBT). Providing an additional augmentation treatment following CBT could help reduce these residual symptoms. Mindfulness interventions that facilitate less reactivity to thoughts and feelings may be helpful for...