Journal of Emotion and Psychopathology
January 20, 2023
Philippe R. Goldin, Amy E. Braun, Eve Ekman et al.
2 citations
Objectives: To investigate outcomes and predictors of a Tibetan Buddhist meditation process called Feeding Your Demons® (FYD) vs. a waitlist (WL) control group of meditation practitioners with moderate depression, anxiety, and stress symptoms. Methods: 61 meditators (70% female; mean age = 44.05, SD = 11.20; 43.5% White, 39% Asian, 9.3% Hispanic, 8.3% other) were randomly assigned to 1-month of...
Frontiers in Psychology
January 19, 2023
Kunhua Lee, Yu-Xuan Lee, Yu-Tung Cheng
ObjectivesThe pandemic has greatly impacted people’s lives and mental health. Therefore, it is now especially important to help people maintain good mental health. The positive effects of mindfulness-based practices on mental health have been demonstrated previously. However, no consensus has yet been reached on the potential mechanisms of mindfulness. This study adopted the two-component model...
Trials
January 19, 2023
Thorsten Barnhofer, Barnaby D. Dunn, Clara Strauss et al.
Background Major depression represents a pressing challenge for health care. In England, Increasing Access to Psychological Therapies (IAPT) services provide evidence-based psychological therapies in a stepped-care approach to patients with depression. While introduction of these services has successfully increased access to therapy, estimates suggest that about 50% of depressed patients who...
ACS Medicinal Chemistry Letters
January 18, 2023
Robert B. Kargbo
2 citations
The renaissance of research into psychedelics class of drugs has renewed interest for a possible psychedelic clinical therapy for treating psychiatric conditions such as treatment-resistant depression, major depressive-disorder, post-traumatic stress disorder, and other neuropsychiatric diseases. Psychedelics are known to stimulate neurogenesis and gliogenesis, reduce inflammation, and...
Journal of Psychedelic Studies
January 18, 2023
Benjamin R. Lewis, Kevin Byrne, John Hendrick et al.
22 citations
Abstract Background Psilocybin-assisted psychotherapy has demonstrated significant promise as a treatment for depression, anxiety, and existential distress associated with serious medical illness and has generally been employed on an individual basis, which presents challenges for scaling and resource availability. There are also compelling theoretical reasons to suggest that group-based...
bioRxiv
January 16, 2023
Anastasiya Zaytseva, Evelina Bouckova, McKennon J. Wiles et al.
preprint
Ketamine is shown to enhance excitatory synaptic drive in the hippocampus, which is presumed to underlie its rapid antidepressant effects. Moreover, ketamine’s therapeutic actions are likely mediated by enhancing neuronal Ca2+ signaling. However, ketamine is a noncompetitive NMDA receptor (NMDAR) antagonist that inhibits excitatory synaptic transmission and postsynaptic Ca2+ signaling. Thus, it...
Anxiety, Stress, and Coping
January 13, 2023
Maarten C. Eisma, Antje Janshen, Lukas S. Huber et al.
24 citations
BACKGROUND AND OBJECTIVES: Maladaptive emotion regulation strategies increase prolonged grief and depressive symptoms following bereavement. However, less is known about the role of adaptive emotion regulation strategies in adaptation to loss. Therefore, we examined the concurrent and longitudinal associations of three putative adaptive emotion regulation strategies (cognitive reappraisal,...
January 13, 2023
Johanna Kreßner, Anja Frank, Mario H W Scheib
preprint
Background: The anesthetic Ketamine has been shown to exert rapid effects in a variety of mental disorders, especially in depression. Recent studies have demonstrated that Ketamine can improve neuroplasticity, the brain’s ability to adapt and form new neuronal connections (Aleksandrova & Phillips, 2021). Aim: To examine the long-term effects of Ketamine without and in combination with other...
Neuropharmacology
January 13, 2023
Jenessa N Johnston, Bashkim Kadriu, Josh Allen et al.
64 citations
The discovery of ketamine as a rapid-acting antidepressant spurred significant research to understand its underlying mechanisms of action and to identify other novel compounds that may act similarly. Serotonergic psychedelics (SPs) have shown initial promise in treating depression, though the challenge of conducting randomized controlled trials with SPs and the necessity of long-term clinical...
Medical alphabet
January 11, 2023
R. K. Kostin, I. A. Rozhnov, E. A. Korabelnikova et al.
1 citation
Aim. To assess the impact of nightmarish dreams on various aspects of medical students' lives. Materials and methods. A sociological survey was conducted among students of 1–6 courses of five medical universities using an online form which included the following questionnaires: the Pittsburgh Sleep Quality Index, the Hamburg Nightmare Questionnaire, the Insomnia Severity Scale, the Hospital...