Psychedelic agents have regained the attention of pharmaceutical companies as promising treatments for depressive episodes. 5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT), an atypical psychedelic, is emerging as a potentially effective, novel rapid-acting antidepressant. In this systematic review, we analyze the safety and tolerability evidence from clinical trials. Following the Preferred...
Objectives: We aimed to examine dream recall and nightmare distress in patients with obstructive sleep apnea (OSA), and identify the associating factors.Methods: This cross-sectional study retrospectively enrolled adult participants (age ≥18 years) with newly diagnosed OSA that was confirmed by full-night polysomnography between 2016 and 2022. Dreaming components were assessed using a nine-item...
Recent developments regarding the pharmacology of psychoactive substances are significant for treating depressions or opioid addictions. Current theories, hypotheses, and models of drug effects assume a cause–effect narrative, which is based on a stimulus/response mechanism. These narratives prioritize effects rather than conscious experiences. In this sense, drug experiences are quickly...
Introduction and purpose: Nowadays, when mental disorders are considered by the World Health Organisation as a global burden, the potential usage of psychedelic drugs as supportive therapy is gaining more attention worldwide. The aim of this paper is to summarize the usefulness of psilocybin - representative of psychedelics - in psychiatric venues. In this review we describe its properties,...
The serotonergic psychedelic psilocybin acutely induces changes in emotional states. However, it remains unresolved whether psilocybin acutely modulates amygdala reactivity to emotions, a brain region critically involved in emotion processing. Using functional magnetic resonance imaging (fMRI), we examined in 26 healthy individuals whether amygdala responses to angry, fearful and neutral faces...
Visão AcadêmicaDecember 29, 2023Nicolly Medeiros Antunes, Ana Gabriela Lodi Palma, Luciane Dalarmi
O Brasil enfrenta uma alta prevalência de depressão, uma doença crônica não transmissível que requer gerenciamento a longo prazo. O tratamento inicial comum envolve medicamentos antidepressivos, mas muitos pacientes não obtêm melhora, resultando em uma depressão resistente ao tratamento, caracterizada pela falta de resposta a múltiplos medicamentos ou terapias. Pesquisas têm explorado...
Mental illness is a hot topic of concern worldwide. The psilocybin has great potential in the treatment of mental disorders, but there is still a research gap on whether it can truly be applied in the treatment of mental disorders. Therefore, this research explores the feasibility of psilocybin’s true application in the treatment of mental disorders by collecting relevant literature on its...
Research showed that one in six of college students in Taiwan suffered from depression. In addition, the World Health Organization also pointed out that global anxiety and depression cases increased by 25% in the first year (2020) of the COVID-19 pandemic. The purpose of this study was to assess if the Mindfulness-Based Cognitive Therapy (MBCT) course could help students improve concentration,...
Health of ManDecember 28, 2023Oksana Kobzar, Galyna Pyliagina
The objective: to analyze the features of the course of depersonalization-derealization disorder (DDD) in men on the example of a clinical case. Materials and methods. The pilot study included 51 individuals, namely: 8 (15.7%) men and 43 (84.3%) women, with average age 21 years (SD=3.66) and 23.86 years (SD=6.88), respectively. Study participants had criteria for DDD according to the...
The reviews in this special edition have presented a primer on the state of the literature for six different psychedelic compounds and their plausible role in medicine. In a common format underscoring strengths, weakness, opportunities, and threats (SWOT), this article addresses how psychedelic compounds fit into the broader healthcare landscape for indicated conditions. Historically,...