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Depression: all studies

Page 643 of 1,034: studies 6,421 to 6,430 of 10,336, newest first. Back to the depression overview

Research

Web-Based Therapist-Guided Mindfulness-Based Cognitive Behavioral Therapy for Body Dysmorphic Disorder: Pilot Randomized Controlled Trial.

JMIR Mental Health June 12, 2024 Camrie Kerry, Prabhdeep Mann, Nazanin Babaei et al. 4 citations

Internet-based cognitive behavioral therapy (CBT) and stand-alone mindfulness meditation interventions are gaining empirical support for a wide variety of mental health conditions. In this study, we test the efficacy of web-based therapist-guided mindfulness-based cognitive behavioral therapy (CBT-M) for body dysmorphic disorder (BDD), a psychiatric disorder characterized by preoccupations with...

DOI: 10.2196/55283 (opens in new tab) Full text (opens in new tab) Bdd OCD Body dysmorphic disorder Cognitive behavior therapy +5

Effects of psilocin and psilocybin on human 5-HT4 serotonin receptors in atrial preparations of transgenic mice and humans

Toxicology Letters June 12, 2024 Joachim Neumann, Kiril Dimov, Karyna Azatsian et al. 5 citations

Several fungi belonging to the genus Psilocybe, also called "magic mushrooms", contain the hallucinogenic drugs psilocybin and psilocin. They are chemically related to serotonin (5-HT). In addition to being abused as drugs, they are now also being discussed or used as a treatment option for depression. Here, we hypothesized that psilocybin and psilocin may act also on cardiac serotonin...

Longitudinal neurofunctional changes in medication overuse headache patients after mindfulness practice in a randomized controlled trial (the MIND-CM study).

The Journal of Headache and Pain June 11, 2024 Davide Fedeli, Giuseppe Ciullo, Greta Demichelis et al. 17 citations

Mindfulness practice has gained interest in the management of Chronic Migraine associated with Medication Overuse Headache (CM-MOH). Mindfulness is characterized by present-moment self-awareness and relies on attention control and emotion regulation, improving headache-related pain management. Mindfulness modulates the Default Mode Network (DMN), Salience Network (SN), and Fronto-Parietal...

DOI: 10.1186/s10194-024-01803-5 (opens in new tab) Full text (opens in new tab) Mindfulness Chronic pain Cortical thickness Functional connectivity +5

Editorial: Down the rabbit hole - the psychological and neural mechanisms of psychedelic compounds and their use in treating mental health and medical conditions.

Frontiers in Psychiatry June 10, 2024 Leehe Peled-Avron, Jacob S. Aday, Amilia Lydia Kalafateli et al. 2 citations

Editorial on the Research Topic Down the rabbit hole -the psychological and neural mechanisms of psychedelic compounds and their use in treating mental health and medical conditions Psychedelic substances have demonstrated promising therapeutic effects across a wide range of mental health conditions including depression (1-13) anxiety disorders including generalized anxiety (14-16) and social...

DOI: 10.3389/fpsyt.2024.1431389 (opens in new tab) Full text (opens in new tab) Mental health Psychedelics Psychiatric treatment Therapeutic research

Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress.

Nature Communications June 10, 2024 Andiara E Freitas, Bo Feng, Timothy Woo et al. 9 citations

Single administration of low-dose ketamine has both acute and sustained anti-depressant effects. Sustained effect is associated with restoration of glutamatergic synapses in medial prefrontal cortic (mFPC) neurons. Ketamine induced profound changes in a number of molecular pathways in a mouse model for chronic stress. Cell-cell communication analyses predicted that planar-cell-polarity (PCP)...

Mindfulness-Based Cognitive Therapy terhadap Penurunan Kecemasan pada Pasien Kanker

Journal of Telenursing June 8, 2024 Ermelinda Toyo Legu, Dewi Gayatri, Agung Waluyo

This research aims to determine the effectiveness of mindfulness-based cognitive therapy in reducing anxiety in cancer patients. The research method used is a systematic review, searching articles in six trusted databases: ProQuest, EBSCOhost, PubMed, Wiley Online Library, SpringerLink, and Google Scholar—article analysis using the PRISMA method. The research results show that mindfulness-based...

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

UNC Libraries June 7, 2024 Kami Kim, Tao Che, Ouliana Panova et al.

Hallucinogens like lysergic acid diethylamide (LSD), psilocybin, and substituted N-benzyl phenylalkylamines are widely used recreationally with psilocybin being considered as a therapeutic for many neuropsychiatric disorders including depression, anxiety, and substance abuse. How psychedelics mediate their actions—both therapeutic and hallucinogenic—are not understood, although activation of...

DOI: 10.17615/yb2v-ca64 (opens in new tab) Serotonin Hallucinogen 5-HT Receptor 5-ht2 receptor +1

Psilocin fosters neuroplasticity in iPSC-derived human cortical neurons

Research Square June 7, 2024 Målin Schmidt, Anne Hoffrichter, Mahnaz Davoudi et al. 5 citations preprint

Abstract Psilocybin is studied as innovative medication in anxiety, substance abuse and treatment-resistant depression. Animal studies show that psychedelics promote neuronal plasticity by strengthening synaptic responses and protein synthesis. However, the exact molecular and cellular changes induced by psilocybin in the human brain are not known. Here, we treated human cortical neurons...

Potencjał terapeutyczny wybranych substancji psychoaktywnych — przegląd najnowszych badań

Psychiatria June 5, 2024 Anna Stankiewicz, Jan Szewczyk, Julia Truszkowska et al. 1 citation

Drug therapies for many psychiatric conditions do not meet patients’ expectations. New agents are being sought to treat depression and anxiety disorders, among others. Scientific interest in psychoactive substances has increased over the past few decades. Recent studies provide evidence that psychedelics may find use in the treatment of a range of mental disorders. This paper describes new...

Microvita and Mental Wellness: A Holistic Conceptual Framework for Subtle Influences on Cognition, Emotion, and Collective Well-Being

International Journal of Linguistics Applied Psychology and Technology June 4, 2024 Dr. Anita Sagar

Mental wellness has emerged as one of the most critical components of public health and human development in the twenty-first century. As global societies confront rising levels of stress, anxiety, depression, and psychological fragmentation, there is a growing interest in integrative frameworks that explore the role of subtle influences on mental states. Microvita, a concept introduced by the...

DOI: 10.69889/ijlapt.v1i1(may).153 (opens in new tab) Meditation Biopsychosocial model Mental health Context archaeology +12