Individuals with addiction, anxiety, depression, existential distress, and post-traumatic stress disorder (PTSD), have experienced rapid and long-lasting relief of debilitating symptoms after ingestion of psychedelics.After experiencing treatment resistance or dropout, patients experienced success with psychedelics they had not with prescribed medicine.The Netherlands (NL) and the United States...
Psychedelic therapies have emerged as a modality of treatment for several treatment resistant diseases, including post-traumatic stress disorder (PTSD), treatment resistant depression, substance use disorders, anxiety, and obsessive-compulsive disorders. Arguably more than with other therapies, their success is dependent on the facilitator and the context of the administration. Several programs...
Psilocybin is an alkaloid known for its psychedelic effects by activating serotonin receptors and there is growing interest in using psilocybin to treat mental disorders such as depression and anxiety, which are not fully understood and difficult to treat with conventional medications. This research aims to review the evidence from preclinical and clinical studies on the use of psilocybin for...
Bipolar II disorder is traditionally understood as a condition of mood dysregulation, yet beneath its psychological manifestations lies a physiological rhythm often overlooked: the regulation of the autonomic nervous system. This perspective proposes that while bipolar II is not caused by a dysregulated nervous system, its course-and particularly the depth and duration of depressive episodes-is...
Pregnancy is a unique experience for every woman, but it is not always easy. A good health indicator in the country is reduced maternal mortality and morbidity. How mindfulness affects maternal mental health parameters such as stress, anxiety, and depression has been well documented. However, their impact on maternal physiological parameters has not been explored much, which is the primary goal...
Abstract Objectives Psychospiritual distress affects many patients with cancer, contributing to diminished quality of life, decreased survival and a desire for hastened death. The current standard of care, which primarily consists of antidepressants and psychotherapy, has demonstrated only modest benefits. Psilocybin-assisted therapy (PAT) has shown evidence of rapid, durable, and significant...
Psilocybin containing mushrooms have been utilized for ceremonial, medicinal, and spiritual purposes for millennia. Recently there has been a surge of scientific interest in the therapeutic potential and mechanistic understanding of serotonergic psychedelics, including psilocybin. Psilocybin is classified as a serotonergic psychedelic because the non-ordinary state of consciousness that it...
2025Henrique Tofoli Vieira Machado, Geovana Mendes de Seixas, L. Silva et al.
Introduction: In recent years, psilocybin has been explored as an alternative therapy for neurological and psychiatric disorders, such as depression, anxiety, post-traumatic stress disorder (PTSD), and substance dependence. Studies suggest that when administered under professional supervision, psilocybin can offer relief for patients with treatment-resistant disorders. Objective: The aim of...
Psilocybin-assisted therapies (PAT) have been used to treat several issues including obsessive-compulsive disorder (OCD), major depressive disorder (MDD), posttraumatic stress disorder (PTSD), smoking addiction, and anxiety (Grob et al., 2011; Johnson et al., 2014; Kisely et a., 2022; Moreno et al., 2006). If more positive benefits of psilocybin are discovered, psilocybin could become a more...
Age-related cognitive decline typically begins during middle age and persists into old age. In parallel, mood (and, in particular, anxiety and depression) can be a significant predictor of neurodegenerative pathologies. To prevent these negative consequences, mindfulness trainings were used to improve mood and executive functioning in middle-aged and older adults. Less is known about cold water...