Psilocibina no Manejo da Depressão e Ansiedade: Uma Revisão Integrativa de Evidências Científicas
Amazônia Science & Health January 1, 2025 Ana Paula Dalmagro, Aline Bianca Montibeler, Michele Andrade
Psilocybin, a psychedelic alkaloid that activates serotonin receptors, is being investigated for treating depression and anxiety. An integrative review of 23 articles from preclinical and clinical studies found that behavioral effects depend on dosage and involve increased neurotrophic factors and 5-HT2A receptor activation. Clinical studies report significant improvements in depression and anxiety symptoms, sometimes after a single dose, with few severe adverse effects. However, the authors note that many studies have limitations requiring further investigation before psilocybin can be established as a viable treatment option.