Frontiers in Pharmacology
2026
Camila Estay-Olmos, Koyam Morales-Weil, Juan Ahumada et al.
The serotonin 2A receptor (5-HT2A) is a Gq/11-coupled receptor implicated in reward processing, neuropsychiatric disorders, and the actions of serotonergic psychedelics. Although 5-HT2A activation has been shown to engage endocannabinoid (eCB) signaling in several brain regions, its role in inhibitory synaptic plasticity within the nucleus accumbens (NAc) remains poorly understood. Here, we...
2026
Yosr Ziadi, Taehwan Park
preprint
Conference poster presented at ISPOR 2026, Philadelphia, May 2026. Co-authors: Yosr Ziadi, Taehwan Park. St. John's University.
2026
Tom Bielen
preprint
Psilocybin-assisted therapy has produced promising results in clinical trials for depression, but most existing reviews treat major depressive disorder (MDD) and treatment-resistant depression (TRD) as a single category. This conflation is a problem. MDD and TRD differ in diagnostic criteria, illness severity, prior treatment failure, and likely neurobiological profile. Pooling their results...
2026
Irina Dell'Orto
preprint
Background: Psilocybin-assisted therapy (PAT) has demonstrated rapid and substantial antidepressant effects in phase 2 RCTs (Davis et al., 2021; Carhart-Harris et al., 2021), and phase 3 trials are now active (Usona uAspire, NCT06308653). However, three critical gaps remain unresolved in 2025: (1) the durability of effects beyond 12 months has not been established in a controlled design; (2)...
2026
Canyon Akromis, Lorraine Li, Kwon Mok Ko et al.
preprint
This project is a secondary analysis of data from Psilocybin in Depression Resistant to Standard Treatments (PsiDeR) study, a phase II, randomised, placebo-controlled clinical trial where participants with treatment resistant depression received either 25 mg of psilocybin or a placebo alongside psychotherapy. This research seeks to determine whether the therapeutic alliance, measured by the...
Journal of Marital and Family Therapy
2026
Matthew E. Jaurequi
ABSTRACT Mindfulness may reduce depression by supporting more satisfying relationships, yet these associations remain understudied in Latino couples. Given the overlap between mindfulness and Latino cultural values, this study tested whether trait mindfulness is linked to greater relationship satisfaction and, in turn, lower depression among Latino couples. Survey data from 293 heterosexual...
2026
Vassilis Martiadis, Fabiola Raffone, Domenico de Berardis
preprint
BACKGROUND: Treatment-resistant depression (TRD) affects approximately one-third of patients with major depressive disorder and represents a critical clinical challenge. Esketamine (S-ketamine, Spravato), approved by FDA and EMA since 2019, and psychedelic-assisted therapies (psilocybin, MDMA) share a pharmacological feature unique among approved psychiatric treatments: they induce altered...
Journal of Medical Excellence
2026
Risha Jatal, Abhishek Samarth, Srushti Deulkar
A BSTRACT Major depressive disorder is commonly associated with suicidal ideation, while conventional antidepressants have a delayed onset of action. Ketamine has emerged as a rapid-acting antidepressant with potential anti-suicidal effects. This retrospective case series evaluated the effectiveness and tolerability of intravenous ketamine in patients with major depressive disorder and active...
Open Mind
2026
Ellen Sallis, Thorsten Barnhofer, Daniel Milburn et al.
preprint
Research to date has focused largely on mindfulness-based interventions as whole treatment packages, with relatively little exploration of the specific mindfulness practices that comprise them. Understanding the effects of individual practices could offer insight into why mindfulness-based interventions work for some but not others and help identify and mitigate any adverse effects. This is in...
Psychological Medicine
2026
Jingjing Xie, Li Li, Xuehua Liu et al.
Abstract Background Nonsuicidal self-injury (NSSI) in adolescents with depressive disorder is characterized by recurrent impulsivity and is a predictor of future suicidal behavior, necessitating effective and feasible interventions. Mindfulness-based cognitive therapy for adolescents (MBCT-A), a first-line treatment for depression, was evaluated in this trial for its efficacy in reducing NSSI...