Introduction Psychedelics, such as psilocybin, are increasingly recognized for their propensity to elicit powerful subjective experiences that carry personal meaning. While research has demonstrated the capacity for these compounds to promote psychological wellbeing, it has yet to be shown to what extent they modulate "meaning in life", a specific contributor to mental and physical health....
Millions worldwide suffer from chronic pain, a complex condition often accompanied by depression and anxiety, highlighting the urgent need for innovative treatments. Classic psychedelics, including psilocybin, lysergic acid diethylamide (LSD), and N,N-dimethyltryptamine (DMT), primarily act on serotonin 5-HT2A receptors and have emerged as potential modulators of pain perception and mood...
June 5, 2025Rima Shah, Apurva Agrawal, Darshil B. Shah et al.
Designer drugs are synthetic analogs of controlled substances engineered to replicate pharmacological effects while circumventing legal restrictions.Their emergence can be traced to the 1960s, with the synthesis of novel psychoactive compounds by chemists like Alexander Shulgin, followed by the proliferation of 3,4-methylenedioxymethamphetamine (MDMA) in the 1980s and synthetic cannabinoids and...
ABSTRACT Academic stress, coupled with the challenges of the modern educational system, has created a need for comprehensive interventions to address the mental health of college students and enhance their positive functioning . This study aimed to determine whether a 4-week mindfulness meditation, guided imagery, and gratitude journaling intervention would be effective in improving college...
However, Yoga is widely regarded as a very old mind body practice with the potential to lead to mental health and wellbeing. In this study, the supplement of Yoga to pharmacotherapy in the management of mental health disorders was investigated. Although no pharmacological interventions still remain the bedrock of treatment for disease such as depression, anxiety or stress related, Yoga has a...
Stress is widely recognized as a major environmental factor contributing to the development of mood disorders. In patients with Major Depressive Disorder (MDD) and suicidal behavior, significant hyperactivation of the hypothalamic-pituitary-adrenal (HPA) axis is observed, characterized by excessive cortisol release, which in turn stimulates the production of pro-inflammatory mediators....
The effectiveness of mindfulness-based interventions (MBIs) in enhancing mental well-being and reducing positive, negative, and depressive symptoms in schizophrenia spectrum disorders (SSD) has been increasingly supported by evidence. However, the underlying mechanisms of MBIs require further examination. Psychological flexibility (PF), typically assessed through cognitive fusion, has been...
Over the past decade, research with psychedelics has gained new momentum, leading to a psychedelic renaissance in both basic and clinical research. Among these substances is ayahuasca, an Amazonian plant medicine used for millennia by indigenous people for ritualistic and healing practices, which has recently entered research labs in the Americas and Europe. Preliminary findings indicate its...
Neurological and psychiatric disorders are considered one of the major problems of today's societies and cause many individual and social problems. Current treatments are effective, but due to their burdens, there is always an effort to introduce novel treatments. Psychedelics, a diverse group of psychoactive compounds, including LSD, psilocybin, DMT, MDMA, and ketamine, have shown potential in...
There is surging interest in the therapeutic potential of psychedelic compounds like psilocybin in the treatment of psychiatric illnesses like major depressive disorder (MDD). Recent studies point to the rapid antidepressant effect of psilocybin; however, the biologic mechanisms underlying these differences remain unknown. This study determines the feasibility of using diffusion MRI to...