Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5-HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5-HT2A receptor ligand bias or signalling efficacy. Here, we investigated 5-HT2A receptor signalling properties of...
Supporting prenatal mental health in women with a preconception history of mental disorders or psychosocial vulnerability is important for a positive transition to parenthood. There is a need for more evidence-based and non-pharmacological mental health interventions in antenatal care. The primary objective of this trial was to evaluate the feasibility of prenatal MBSR, which is an adaption of...
This study investigated the feasibility and psychological benefits of a two-day intensive forest therapy program incorporating mindfulness practices for individuals affected by natural disasters. The sample comprised 110 participants, including those who had either experienced wildfires or floods or served as first responders. The results revealed significant reductions in depression, anxiety,...
Depression in old age is a public health concern contributing to individual and societal burdens. Mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) have shown promise in reducing depressive symptoms. However, time commitments associated with these interventions could pose challenges to older adults. To address this, we propose a briefer mindfulness-based...
Ketamine, a rapid-acting N-methyl-D-aspartate receptor antagonist used as a therapeutic for treatment-resistant depression (TRD), is usually administered intravenously or intranasally. This randomized, double-blind, placebo-controlled, Phase 1 study investigated safety and tolerability (primary endpoint), pharmacokinetics (PK) and pharmacodynamics (PD) of an immediate-release oral ketamine....
The development of new drugs is a complex, expensive, and time-consuming process, often fraught with a high likelihood of failure. Amid these obstacles, drug repurposing, which identifies new therapeutic applications for already existing medications, offers a more economical and time-saving approach, particularly in the challenging field of neurological and psychiatric disorders. This narrative...
NeuropsychologiaJune 19, 2025Sam Fisher-Hicks, Victoria Lovett, Rodger Ll Wood et al.
Mesial frontal and temporoparietal brain areas differ in activity between high and low dream recallers, and lesion studies have found cessation of dreaming in patients with damage to these areas. This study extends these findings by assessing the relationship of dream cessation, and dream and nightmare frequencies, to severity of injury in patients at a head trauma clinic. 52 participants (M =...
The purpose of this research is to investigate developing misuse of certain psychotropic substances, depressants, hypnotics & stimulant drugs. The research is intended to generate a uniform understanding over cruel usage of certain drugs; in diminishing attentiveness, reducing senses & disturbing logical / cognitive skills. This guide is essential to understand how predatory drugs initiate...
Treatment-resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined. Here, we review the current literature on the genetics of response to these treatment modalities. To...
Dissociative experiences are prevalent in young people, where they are associated with greater clinical severity of co-occurring difficulties and increased risk of self-harm and suicide. Recent research suggests transdiagnostic dissociation plays a role in the development and maintenance of mental health problems such as anxiety, depression and psychosis, and may therefore constitute a novel...