American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
June 17, 2025
Clio E Franklin, Murat Altinay, Kala Bailey et al.
2 citations
Treatment-resistant mood disorders are often managed with intensive interventions that include electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), ketamine, and esketamine, but the role of genetics in clinical response to those interventions is yet to be clearly determined. Here, we review the current literature on the genetics of response to these treatment modalities. To...
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
December 2011
Xiangdong Deng, Hiromi Takaki, Lixiang Wang et al.
As schizophrenia-like symptoms are produced by administration of phencyclidine (PCP), a noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, PCP-responsive genes could be involved in the pathophysiology of schizophrenia. We injected PCP to Wistar rats and isolated five different parts of the brain in 1 and 4 hr after the injection. We analyzed the gene expression induced by the...
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
July 5, 2007
Rachel F. Tyndale, Jennifer I Payne, Alexandra L Gerber et al.
A genetic variation in fatty acid amide hydrolase (FAAH), C385A (P129T), has been previously associated with risk for problem street drug use. FAAH is a mammalian enzyme that inactivates neuromodulatory-signaling lipids including the endogenous cannabinoid 1 receptor agonist anandamide. We investigated in adult Caucasians (N = 749) whether this FAAH variant altered the risk for trying, regular...
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
August 5, 2005
Cristina Lorenzi, Alessandro Serretti, Laura Mandelli et al.
Recently, an association between serotonin 1A receptor binding potential and self-transcendence scores at the temperament and character inventory (TCI) has been reported. We tested involvement of 5-HT(1A) gene in this trait, in a sample of 40 remitted mood disorder patients. Subjects with the 5-HT(1A)*C/C genotype showed significantly lower scores at the total self-transcendence and at the...
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
June 17, 2005
Ulrich Ott, Martin Reuter, Juergen Hennig et al.
96 citations
Absorption represents a disposition to experience altered states of consciousness characterized by intensively focused attention. It is correlated with hypnotic susceptibility and includes phenomena ranging from vivid perceptions and imaginations to mystical experiences. Based on the assumption that drug-induced and naturally occurring mystical experiences share common neural mechanisms, we...