Neurologic Clinics
February 1, 2026
Mina Ansari, Sophie I Elliott, Sophie E Holmes et al.
1 citation
The development of novel, rapid-acting treatments and the resurgence of interest in the therapeutic potential of psychedelic-like compounds has stimulated excitement and enthusiasm within the pharmaceutical industry, and provided new hope for millions of individuals suffering with mental illness such as major depressive disorder and post-traumatic stress disorder. This review summarizes the...
Journal of Social Sciences and Humanities
January 31, 2026
Mohammad Jawad Mirzaee
Depression is highly prevalent among university students worldwide, yet evidence from Afghanistan is limited. This study examined the protective roles of spirituality, mindfulness, and hope against depression among 450 undergraduate and master’s students from four universities in Kabul during the 2025 academic year. The sample was predominantly young adults, with 43.1% aged 18–22 years and...
Cureus
January 31, 2026
Lukasz Siwek, Marta Nowocien, Barbara Balajewicz et al.
Psilocybin is a psychoactive chemical compound that exerts its effects through the activation of serotonergic receptors. It occurs naturally in mushrooms of the genus Psilocybe. Despite its potential medical applications, this substance is regarded as a drug with no recognized medical use. Depression constitutes a psychiatric disorder of substantial global burden, affecting millions of...
International Journal of Medical Sciences
January 30, 2026
Effect of Virtual Reality-Based Mindfulness Program vs Audio-Guided Mindfulness on Depression, Sleep, and Quality of Life in Dementia Family Caregivers: An Exploratory Randomized Controlled Trial.
Journal of Affective Disorders
January 30, 2026
Yao-Zu Li, Cai-Qun Zhao, Mu-Yan Zuo et al.
To evaluate the efficacy and safety of a multimodal rapid anti-depression therapy that combines esketamine treatment with dexmedetomidine patient-controlled sleep (PCSL) in patients with treatment-resistant depression (TRD). We retrospectively included 233 patients with TRD who received the multimodal treatment. Baseline clinical characteristics were collected. Follow-up assessments were...
Gaceta Médica de Caracas
January 29, 2026
Wachidah Yuniartika
Introduction: Depression among older adults is a multifaceted public health concern influenced by factors such as spousal loss, social isolation, and biological and psychological changes. Mindful yoga therapy, integrating gentle physical movements with mindfulness practices, offers a non-pharmacological approach to improving mental health in this population.
Translational Psychiatry
January 29, 2026
Rafael V Lima Da Cruz, Rêmullo B. G. De Miranda Costa, Gabriel M. De Queiroz et al.
2 citations
Major depressive disorder (MDD) remains a leading cause of disability worldwide, with current treatments limited by delayed onset and low efficacy. The serotonergic psychedelic N,N-dimethyltryptamine (DMT) has shown rapid antidepressant effects in early clinical studies, yet its mechanisms and efficacy remain poorly characterized in established models of depression. Here, we evaluated the...
European journal of anaesthesiology
January 29, 2026
Tiantian Chu, Xiaoling Peng, Keliang Wan et al.
2 citations
Postpartum depression (PPD) is a common complication after childbirth, especially in primiparae. This trial sought to evaluate whether prophylactic administration of esketamine during the perinatal period could prevent PPD in primiparae without predisposition to prenatal depression. A prospective, double-blind, multicentre, randomised controlled trial. Three academic hospitals. Primiparae...
The Journal of ECT
January 29, 2026
Sergi López-rodríguez, Aida De Arriba-Arnau, José Manuel Menchón et al.
1 citation
This case series describes the combined use of electroconvulsive therapy (ECT) and intranasal esketamine (ESK)-2 rapidly acting, evidence-based options for treatment-resistant depression (TRD). Each can leave residual symptoms or early relapse. Whether concurrent use confers more durable benefit remains unclear. We followed 4 adults (50 to 72 y) with severe TRD who had shown partial or waning...
Psychology and Mental Health Care
January 28, 2026
Kianoush Saberi *
Transition to work requires the female students to be compatible with new environments, situations and people that often lead to depression, stress, anxiety and ambiguity. In order to overcome this issue, the concept of mindfulness delivers mental health and welfare notably in depressive and stressful situation as well as feelings of anxiety and concern. Thus, an endeavor in this paper has been...