CJEMJune 3, 2026Yury Onikashvili, Heather Burt, Garth Meckler et al.
ObjectivesEmergency department (ED) visits by adolescents with suicidal ideation have increased, with no rapid-acting treatments identified for ED use. This pilot study explored the feasibility of a randomized controlled trial of ketamine in the ED for adolescents with suicidal ideation.MethodsThree-arm, triple-blinded randomized controlled trial comparing intravenous ketamine (0.5 mg/kg),...
Substance use and behavioral addictions are escalating on a global scale. The Global Burden of Disease Study underscores a rising impact on disability-adjusted life years attributable to substance use. This challenge influences families, communities, healthcare infrastructure, and legal systems; nevertheless, the majority of individuals suffering from substance use disorders face challenges in...
Objective: This study aimed to investigate the effects of a combined regimen of short-term mindfulness (STM) and acupressure on preoperative mood and physiological responses in patients undergoing heart valve replacement (HVR). Methods: A randomized controlled study was conducted in 62 patients admitted to the Department of Cardiac Surgery of a tertiary hospital in Guizhou from May to October...
Research has established that higher trait mindfulness is inversely associated with psychopathology in cross-sectional and longitudinal studies, and research has also demonstrated that mindfulness-based interventions increase trait mindfulness over time. The present study sought to investigate the trajectory of mindfulness development by examining whether repeated practice of state mindfulness...
High rates of recidivism persist among incarcerated men, particularly those with extensive trauma histories, while many rehabilitation programs remain primarily cognitively focused. This systematic review synthesizes evidence on experiential psychotherapies, including mindfulness-based interventions, Acceptance and Commitment Therapy (ACT), yoga, meditation, and creative arts therapies...
Abstract Background Prolonged grief disorder (PGD) is a clinically distinguishable bereavement-related condition characterized by persistent yearning, identity disruption, and impaired functioning, formalized in DSM-5-TR and ICD-11 (6L72) and empirically distinguishable from but frequently co-occurring with major depressive disorder. Approximately 7 to 10 percent of bereaved adults meet...
Background/Objectives: Patients in palliative care frequently experience multidimensional suffering that extends beyond physical symptoms to include existential distress, demoralization, and loss of meaning. Psychedelic-assisted therapies (PAT), including ketamine-assisted psychotherapy (KAP), have re-emerged as promising interventions for these domains. This study aimed to provide a narrative...
Classical serotonergic psychedelics, such as psilocybin, show emerging evidence of therapeutic potential across a range of mental health disorders, including depression, anxiety, and substance use disorders, with indications of transdiagnostic efficacy. While early-phase studies yielded encouraging results, recent larger-scale phase 3 trials, such as those evaluating psilocybin for...
Psilocybin, the main psychoactive compound in Psilocybe cubensis mushrooms, has gained considerable attention for its therapeutic potential. Current research focuses only on isolated psilocybin, neglecting the broader pharmacological and cultural use of the whole mushroom. This perspective advocates for an integrative approach that includes standardised P. cubensis extracts within the...
Introduction Multiple sclerosis (MS) is a chronic neuroinflammatory disorder frequently associated with psychiatric comorbidities such as depression, anxiety, bipolar disorder, and psychosis. However, dissociative disorders in MS are rarely reported and remain underexplored. Dissociative amnesia accompanied by regressive behaviors is likely influenced by both the psychological burden of MS and...