Molecular biotechnology
2025
Fatima Iftikhar Shah, Somia Shehzadi, Fatima Akram et al.
2 citations
Depression, a global health concern with significant implications for suicide rates, remains challenging to treat effectively with conventional pharmacological options. The existing pharmaceutical interventions for these illnesses need daily dosing, are accompanied by various adverse effects, and may exhibit limited efficacy in certain cases. However, hope emerges from an unlikely...
Neuropsychiatric Disease and Treatment
2025
Daniel A Kinderlehrer
13 citations
The incidence of mental health disorders is increasing worldwide. While there are multiple factors contributing to this problem, neuroinflammation underlies a significant subset of psychiatric conditions, particularly major depressive and anxiety disorders. Anti-inflammatory interventions have demonstrated benefit in these conditions. Psilocin, the active ingredient of mushrooms in the...
Frontiers in Neuroanatomy
2025
Wigínio Gabriel de Lira-Bandeira, Lílian Andrade Carlos de Mendonça Batista, Andréa Silva de Medeiros Bandeira et al.
4 citations
The striatum (St) integrates cognitive, motor, and limbic functions and plays a critical role in processing emotions, motivation, and rewards. It may undergo several morphophysiological changes in neuropsychiatric diseases. Depression, a complex psychiatric disorder, affects millions of people around the world and leads to an increased risk of suicide, decreased quality of life, and functional...
Frontiers in Psychiatry
2025
Sofia Abramsky-Sze, Elliot Marseille, Richard Matzopoulos et al.
4 citations
Few population-based studies have examined associations between psychedelic use and mental health outcomes. This work describes characteristics of exclusive psychedelic mushroom use (referred to as PM use), PMs in combination with other psychedelic substances (multi-psychedelic or MP) use, and non-psychedelic use and explores mental health ratings in non-clinical settings. This work uses...
Phainomena
December 29, 2024
Jon Stewart
The present article examines the contribution to the problem of nihilism found in the American philosopher and psychologist William James, specifically in his essay “Is Life Worth Living?” from 1896 and the chapter “The Sick Soul” from his The Varieties of Religious Experience from 1902. At the age of 27, James suffered a period of intense depression that lasted from the fall of 1869 until the...
Scientific Reports
December 28, 2024
Mei Chih Liao, Ming Sing Jessica Choi, Chak Hei Ocean Huang et al.
2 citations
Loneliness has been recognized as a pressing global health threat. Research shows that loneliness is associated with depressive symptoms, but less is known about what factors might influence this relationship. This study tested the hypothesis that mindfulness would buffer the association between loneliness and depressive symptoms. A total of 220 Chinese adults completed validated measures of...
Brain Sciences
December 22, 2024
Clarissa A Moura, Anne N de Sousa-Silva, Ana Lívia Mesquita Soares et al.
1 citation
Recent studies have investigated the effects of ketamine on fear memory in animals. However, it is unclear if ketamine might affect avoidance memory and emotional behaviors concomitantly. In this study, we compared the effects of (R,S)- and (S)-ketamine in modulating avoidance responses, depression- and anxiety-related behaviors in stressed mice. Mice were previously exposed to inescapable...
Progress in Neuro-Psychopharmacology and Biological Psychiatry
December 20, 2024
Veronica Grasso, Gilmar Gutierrez, Najat Alzbeidi et al.
9 citations
Unipolar treatment-resistant depression (MDD-TRD) is associated with neurocognitive impairment. Ketamine, an emerging treatment for MDD-TRD, may have neurocognitive benefits, but evidence remains limited. We conducted a systematic search on EMBASE, Google Scholar, PsycINFO, and PubMed and included studies exploring the cognitive effects of intravenous (IV) ketamine treatment in the management...
JMIR bioinformatics and biotechnology
December 16, 2024
Jayaram Thimmapuram, Kamlesh D Patel, Deepti Bhatt et al.
2 citations
Health care students often experience high levels of stress, anxiety, and mental health issues, making it crucial to address these challenges. Variations in stress levels may be associated with changes in dehydroepiandrosterone sulfate (DHEA-S) and interleukin-6 (IL-6) levels and gene expression. Meditative practices have demonstrated effectiveness in reducing stress and improving mental...
Journal of Affective Disorders
December 15, 2024
Liva G Lamontagne, Jennifer L Doty, David C Diehl et al.
11 citations
Preventing anxiety and depression among college students is a pressing public health need. Recent meta-analyses have examined mobile mindfulness interventions in adult populations; however, college students are in a unique developmental stage and institutional setting. We conducted a systematic literature review and meta-analysis of published and unpublished studies in English language on the...