Biological Psychiatry
July 7, 2025
Cory B Langreck, Briana K Chen, Victor M Luna et al.
9 citations
Contradictory evidence has emerged regarding the role of the mu opioid receptor (MOR) in the antidepressant actions of (R,S)-ketamine. Here, we used the long-acting MOR-selective antagonist methocinnamox (MCAM) to determine the contribution of MOR to the actions of (R,S)-ketamine and the more selective N-methyl-D-aspartate receptor (NMDAR) antagonist fluoroethylnormemantine (FENM) against...
European Journal of Pharmacology
July 5, 2025
Jolien K E Veraart, Sanne Y Smith-Apeldoorn, Jeanine Kamphuis et al.
2 citations
Oral esketamine has relatively low and variable bioavailability, which may complicate broader use as an antidepressant. This study aimed to investigate associations between different pharmacokinetic outcomes and change in depressive symptoms following oral esketamine administration in patients with treatment-resistant depression. Understanding such associations may inform dosing and...
BMC Women's Health
July 4, 2025
Federica Facchin, Francesca Grosso, Emanuela Saita et al.
Background: Endometriosis presents diagnostic challenges and has profound impacts, encompassing physical and psychological symptoms, relationship difficulties, and disruptions in daily life. The emotional burden is pervasive, intensified by feelings of anxiety, depression, guilt, and shame. Despite extensive exploration of risk factors such as pelvic pain, knowledge about protective factors for...
Pediatric cardiology
July 2, 2025
Vicki A Freedenberg, Rachel Steury, Robert Podolsky et al.
Adults with congenital heart disease (ACHD) have high rates of anxiety and depression. Strategies to manage the stress of having a chronic disease, improve coping skills and resilience can reduce these rates. To examine the effectiveness of an ACHD-specific, real-time virtual mindfulness-based behavioral intervention (MBBI) on mental health and resilience. A randomized wait-list control study...
Journal of Psychoactive Drugs
July 2, 2025
Grace Stockwell, Nicholas Hoeh, Francesca Fogarty et al.
2 citations
Ketamine-assisted therapy (KAT) is a novel modality that shows promise as a treatment for depression. The current study sought to add to the scarce research in the area and inform future applications of KAT for patients with treatment-resistant depression. The study used in-depth qualitative interviews (N = 12) to explore participants' perceptions of KAT, including working with therapists, the...
Journal of Nursing Scholarship
July 1, 2025
Shaimaa Mohamed Amin, Heba Emad El-Gazar, Mohamed Ali Zoromba et al.
15 citations
Menopause is associated with significant physical, psychosocial, and emotional changes that can negatively affect women's quality of life (QoL). In response to this, psychological interventions like mindfulness-based interventions have shown promise in alleviating menopausal symptoms and improving psychological well-being. A comprehensive randomized controlled trial was conducted from May to...
Australian critical care : official journal of the Confederation of Australian Critical Care Nurses
July 1, 2025
Meilin Liu, Ya Guo, Jing Bai et al.
7 citations
Mindfulness-based interventions may contribute to the mental health status and well-being of nurses. Current results are inconsistent, and there are no systematic review and meta-analyses for intensive care unit (ICU) nurses. The aim of this study was to assess the effectiveness of mindfulness-based interventions on psychosocial well-being and occupational-related outcomes among nurses in the...
Psychoneuroendocrinology
July 1, 2025
Ece Idil, Bahar Yuksel, Zeynep Sen et al.
2 citations
Ketamine is a rapid-acting antidepressant with sexually dimorphic effects. Female animals exhibit a higher sensitivity to its antidepressant properties, which has been associated with their ovarian hormone levels. One factor contributing to this sex difference is the faster rate of ketamine metabolism observed in females, potentially regulated by estrogen receptor alpha (ERα) through modulation...
Current Oncology
June 30, 2025
Haley D M Schuman, Chantal Savard, Raèf Mina et al.
9 citations
This systematic review and meta-analysis evaluates (1) the effectiveness of psychedelic-assisted therapy (PAT) using psilocybin and ketamine for psychosocial symptoms in adults with cancer, (2) contextualizes findings with non-randomized and exploratory studies of other psychedelics, and (3) examines the role of therapeutic frameworks in shaping outcomes. We searched PubMed, Cochrane Library,...
Journal of Psychopharmacology
June 30, 2025
Jess Kerr-Gaffney, Anna Tröger, Alice Caulfield et al.
6 citations
Ketamine has emerged as a putative rapid-acting treatment option for psychiatric disorders, particularly treatment-resistant depression. Chronic recreational ketamine use is associated with ketamine-induced urological toxicity, raising concerns over the safety of repeated ketamine treatments. This systematic review aimed to synthesise urological findings from clinical trials and observational...