Pharmaceuticals
July 13, 2020
David Feifel, David Dadiomov, Kelly C. Lee
The objective of this study was to investigate the safety of repeated parenteral ketamine for depression. An electronic survey inquiring about the frequency of adverse events was distributed to providers of parenteral ketamine for depression. In addition, the investigators conducted a search of published studies describing six or more repeated parenteral ketamine treatments administered to...
Neurochemistry International
July 8, 2020
A. Camargo, A. P. Dalmagro, Julia M. Rosa et al.
Augmentative treatment is considered the best second-option when a first-choice drug has partial limitations, particularly by allowing antidepressant dose reduction. Considering that ketamine has significant knock-on effects, this study investigated the effects of single coadministration with subthreshold doses of ketamine plus guanosine in a corticosterone (CORT)-induced animal model of...
July 1, 2020
Nathaniel A. Shanok, Carol Reive, Krystal D. Mize et al.
Abstract. Mindfulness meditation interventions (MMIs) are formal training programs which utilize mindfulness techniques to improve attentional control and reduce stress and anxiety. Past investigat...
Journal of Nursing Science Update
June 30, 2020
Maria Julieta Esperanca Naibili, Iman Permana
Depression is a common mental disorder that is leading cause of disability in the world by 2020 and a major contributor to overall global disease burden. Globally, more than 300 million people of all ages suffer from depression and more women. Depression can affect aspects of life including psychological, physical, and social. MBCT teaches patients through the mind, feelings, and body...
Translational Psychiatry
June 26, 2020
Paulo R Shiroma, Paul Thuras, Joseph Wels et al.
112 citations
The strategy of repeated ketamine in open-label and saline-control studies of treatment-resistant depression suggested greater antidepressant response beyond a single ketamine. However, consensus guideline stated the lack of evidence to support frequent ketamine administration. We compared the efficacy and safety of single vs. six repeated ketamine using midazolam as active placebo. Subjects...
General Psychiatry
June 18, 2020
Xiao-Mei Li, Zhan-Ming Shi, Hua Hu et al.
13 citations
Background The use of ketamine in electroconvulsive therapy (ECT) has been examined in the treatment of major depressive disorder (MDD); however, there has been no systematic review and meta-analysis of related randomised controlled trials (RCTs).Aim To examine the efficacy and safety of ketamine augmentation of ECT in MDD treatment.Methods Two reviewers searched Chinese (China National...
JMIR Mental Health
June 17, 2020
Christo El Morr, Paul Ritvo, F. Ahmad et al.
Background A student mental health crisis is increasingly acknowledged and will only intensify with the COVID-19 crisis. Given accessibility of methods with demonstrated efficacy in reducing depression and anxiety (eg, mindfulness meditation and cognitive behavioral therapy [CBT]) and limitations imposed by geographic obstructions and localized expertise, web-based alternatives have become...
Molecular Brain
June 16, 2020
L. Aleksandrova, Y. Wang, A. Phillips
87 citations
Accumulating evidence implicates dysregulation of hippocampal synaptic plasticity in the pathophysiology of depression. However, the effects of ketamine on synaptic plasticity and their contribution to its mechanism of action as an antidepressant, are still unclear. We investigated ketamine’s effects on in vivo dorsal hippocampal (dHPC) synaptic plasticity and their role in mediating aspects of...
International Journal of Geriatric Psychiatry
June 11, 2020
Elena Dikaios, Sophia Escobar, Marouane Nassim et al.
Mindfulness‐based cognitive therapy (MBCT) is a novel treatment for depression. Our published randomized controlled trial shows that MBCT improves symptoms of late‐life depression (LLD) and anxiety (LLA). We now examine whether continuation sessions of MBCT (MBCT‐C) can prevent LLD/LLA symptom recurrence.
International Review of Psychiatry
June 5, 2020
Ben Carter, Rebecca Strawbridge, Muhammad Ishrat Husain et al.
45 citations
Most interventions for treatment-resistant depression (TRD) are added as augmenters. We aimed to determine the relative effectiveness of augmentation treatments for TRD. This systematic review and network meta-analysis (NMA) sought all randomized trials of pharmacological and psychological augmentation interventions for adults meeting the most common clinical criteria for TRD. The NMA compared...