PozadĂ: Tato studie zkoumĂĄ dopad trĂŠninkovĂŠho programu zamÄĹenĂŠho na sniĹžovĂĄnĂ stresu, deprese a Ăşzkosti na zĂĄkladÄ vĹĄĂmavosti u zdravotnĂch sester v Maroku. Metody: ĂÄastnĂci byli vybrĂĄni z nemocnice v provincii Tetouan v Maroku. Jednalo se o 80 nemocniÄnĂch sester, 59 Ĺžen a 21 muŞů. Byli nĂĄhodnÄ rozdÄleni do intervenÄnĂ skupiny a kontrolnĂ skupiny, v kaĹždĂŠ...
In recent times, there has been increasing interest in utilizing EEG-based techniques for studying Major Depressive Disorder as a dynamic method. Although it is frequently used for identifying depression, the method is still difficult to interpret. The conventional treatment of MDD involves medications such as Selective Serotonin Reuptake Inhibitors, which often have adverse effects. On the...
The country is the first to make psilocybin and MDMA available for medical use by prescription as part of a psychedelic-assisted psychotherapy regimen. In a move that excited some and concerned others, Australia’s Therapeutic Goods Administration (TGA) earlier this year approved the use of MDMA and psilocybin as adjuncts in the treatment of posttraumatic stress disorder (PTSD) and...
Among the greatest unmet needs in major depressive disorder (MDD) is a lack of effective pharmacotherapies for patients who do not respond to first- and second-line antidepressant medications. After decades of muted progress, optimism regarding the future of MDD therapy rose after scientists serendipitously uncovered the antidepressant effects of ketamine. The discovery of ketamine's...
Abstract Background Major depressive disorder (MDD) is a highly prevalent (8–15%), severely disabling disorder and is associated with enormous socioeconomic impact. Antidepressant medication for the treatment of MDD has proven effective in RCTs; however, placebo response is also substantial. Given the potential benefits of modulating the placebo response in patient care and pharmacological...
Abstract: Background: Esketamine (ESK) nasal spray, taken with oral antidepressant therapy, is approved for the treatment of depressive symptoms in adults with major depressive disorder (MDD) with acute suicidal ideation or behavior. In pooled analyses of two pivotal phase 3 studies, ASPIRE I and II, remission rates were consistently higher among patients with MDD with active suicidality who...
Renato de Filippis received travel grants and/or speaker/consultant fees from Janssen-Cilag. Pasquale De Fazio declares that the research was conducted without any commercial or financial relationship that could be construed as a potential conflict of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1. Please...
Introduction: This study examined the efficacy of an 8-week occupational therapy program incorporating mindfulness (MOT) as a form of psychiatric rehabilitation to ameliorate residual social and occupational impairment in patients with anxiety disorders and depression. The objective was to evaluate the effects of MOT on their personal well-being and to assess the impact of MOT on brain function...
Background and Objective: The present study aimed to determine the effect of mindfulness group training on anxiety, stress, and depression in mothers with children with learning disabilities. Materials and Methods: A clinical trial was performed with the participation of 60 mothers with children suffering from learning disabilities in 2021 in Qazvin City, Iran. The participants were divided...
Background: Treatment-resistant depression (TRD) is a chronic illness requiring long-term treatment. Esketamine nasal spray (ESK) has been studied in several long-term trials of patients with TRD, including SUSTAIN-1 (NCT02493868) and SUSTAIN-3 (NCT02782104). This subgroup analysis of SUSTAIN-3 evaluated patients with TRD who received a second induction (IND) and maintenance treatment with ESK...