Frontiers in Neuroscience
2022
Isaac Ostlund, Michael Von Gunten, Calvin Smith et al.
The ventral tegmental area (VTA) mediates incentive salience and reward prediction error through dopamine (DA) neurons that are regulated by local VTA GABA neurons. In young mice, VTA GABA cells exhibit a form of synaptic plasticity known as long-term depression (LTD) that is dependent on cannabinoid 1 (CB1) receptors preceded by metabotropic glutamate receptor 5 (mGluR5) signaling to induce...
Frontiers in Psychiatry
2022
Sarah Beggiato, Alessandro Ieraci, Mariachiara Zuccarini et al.
Cannabis abuse during adolescence is a risk factor for cognitive impairments in psychiatric disorders later in life. To date, the possible causal relationship between cannabinoids, kynurenic acid (KYNA; i.e., a neuroactive metabolite of tryptophan degradation) and cognition has not been investigated in adolescence. Early exposure to delta 9-tetrahydrocannabinol (THC; i.e., the main psychotropic...
2022
Raphael Carvalho Beraldo
A esquizofrenia é uma doença complexa que apresenta grande espectro de sintomas. Entre eles estão os sintomas positivos, negativos e cognitivos que interferem de forma determinante na vida do indivíduo, caracterizando-se uma doença de grande estigma na sociedade. Por ser complexa, sua etiologia ainda é pouco elucidada se baseando, atualmente, em duas principais teorias: dopaminérgica e a do...
eNeuro
2022
Mohammed H Sarikahya, Samantha Cousineau, Marta De Felice et al.
Despite increased prevalence of maternal cannabis use, little is understood regarding potential long-term effects of prenatal cannabis exposure (PCE) on neurodevelopmental outcomes. While neurodevelopmental cannabis exposure increases the risk of developing affective/mood disorders in adulthood, the precise neuropathophysiological mechanisms in male and female offspring are largely unknown....
Neurobiology of Disease
January 2022
Aliza A Le, Julian Quintanilla, Mohammad Amani et al.
There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little is known about effects of early life cannabis exposure on synaptic operations that are critical for encoding and organizing information. We report here that a 14-day course of daily Δ9-tetrahydrocannabinol treatments administered to adolescent rats and mice (aTHC) leads to...
Abstracts from the 2021 Virtual Scientific Meeting of the Research Society on Marijuana July 23rd, 2021
2022
Ari P. Kirshenbaum, C. Lewis, A. Kaplan
The degree to which frequent users of cannabis experience cognitive impairment from acute self-administration has been questioned on the basis of behavioral tolerance to THC. "Indicator" is a downloadable mobile software app that assesses cognitive, perceptual, and motor skills using a variety of brief videogames. In the course of one month (April 2021), the app was used by 199 adult users who...
Journal of Psychiatric Research
2022
E. Kline, M. Ferrara, Fang-Yong Li et al.
Cannabis has been implicated as both a potential cause and adverse prognostic factor in psychotic disorders. Investigating the contributory role of cannabis toward the overall burden of psychotic illnesses may represent an important step toward psychosis prevention and treatment. The current study samples consecutive admissions (N = 246) to two community based first-episode psychosis services...
Psychiatry Research
2022
Lauren V. Moran, E. Tsang, D. Öngür et al.
The 2017 National Inpatient Sample database was utilized to investigate the association between cannabis legalization in the United States and hospitalizations for psychosis associated with cannabis use. We compared the odds of hospital discharges for psychosis associated with cannabis use in adults between the Pacific census division (where most states legalized recreational cannabis use) and...
PLoS One
2022
Hollis C Karoly, Mark A. Prince, Noah N Emery et al.
Cannabis is commonly used among people who drink alcohol, yet evidence on acute effects of co-use is conflicting. Two important variables that may influence the effects of cannabis and alcohol are cannabinoid content (i.e., the ratio of cannabidiol [CBD] and 9-tetrahydrocannabinol [THC]) as well as the order of use (i.e., cannabis before alcohol vs. alcohol before cannabis). Research is mixed...
Drug Science, Policy and Law
2022
Petter Grahl Johnstad
Researchers have associated cannabis use with risk for psychosis, cognitive impairment, and traffic accident. However, this review shows that the association between moderate cannabis use and psychosis is no stronger, and often considerably weaker, than the corresponding association for moderate tobacco use. The same holds for associations with cognitive impairment. For the risk of traffic...