Experimental and Clinical Psychopharmacology
June 2011
Staci A Gruber, Marisa M Silveri, Mary Kathryn Dahlgren et al.
Difficulty monitoring and inhibiting impulsive behaviors has been reported in marijuana (MJ) smokers; neuroimaging studies, which examined frontal systems in chronic MJ smokers, have reported alterations during inhibitory tasks. Diffusion tensor imaging (DTI) provides a quantitative estimate of white matter integrity at the microstructural level. We applied DTI, clinical ratings, and...
Neuropsychopharmacology
June 2011
Toby T Winton-Brown, Paul Allen, Sagnik Bhattacharyya et al.
Although the effects of cannabis on perception are well documented, little is known about their neural basis or how these may contribute to the formation of psychotic symptoms. We used functional magnetic resonance imaging (fMRI) to assess the effects of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) during visual and auditory processing in healthy volunteers. In total, 14 healthy...
Current Drug Abuse Reviews
June 1, 2011
Sybille Schulz
15 citations
Although the prevalence of co-use of cannabis and 3,4 methylenedioxymethamphetamine (MDMA) is very common among polydrug users in western societies, few studies have tested the consequences on behavior, cognition or neurobiology. This review examines 23 articles published between 2002 and 2010 with an explicit focus on the combination, or administration, of MDMA and cannabis or cannabinoid...
The British Journal of Psychiatry
May 31, 2011
Maria Alice Fontes, Karen I Bolla, Paulo Jannuzzi Cunha et al.
300 citations
BACKGROUND: Many studies have suggested that adolescence is a period of particular vulnerability to neurocognitive effects associated with substance misuse. However, few large studies have measured differences in cognitive performance between chronic cannabis users who started in early adolescence (before age 15) with those who started later. AIMS: To examine the executive functioning of...
Acta Psychiatrica Scandinavica
May 2011
Chris D Schubart, Marco P Boks, E J Breetvelt et al.
To investigate the relationship between cannabis use and mental health. A cross-sectional analysis in a sample of 17 698 individuals with a mean age of 22 years (SD: 4.2). Participants provided information on the amount and initial age of cannabis use and history of psychiatric hospitalizations through a web-based questionnaire. To quantify Δ(9) -tetrahydrocannabinol exposure, we...
Dusunen Adam: The Journal of Psychiatry and Neurological Sciences
April 21, 2011
Gökhan Umut, İlker Küçükparlak, Güliz Özgen et al.
2 citations
A mood disorder episode with an onset under chronic cannabis consumption and accompanied with psychotic features immediately after N,N-Dimethyltryptamine (DMT) use: case report N,N-dimethyltryptamine (DMT) is a serotonin agonist hallucinogen, similar to lysergic acid diethylamide (LSD).Synthetic production of DMT as well as extraction from several plants of South American flora is possible.DMT...
The International Journal of Neuropsychopharmacology
April 14, 2011
Hendrika H Van Hell, Matthijs G. Bossong, Gerry Jager et al.
61 citations
The main reason for recreational use of cannabis is the 'high', the primary psychotropic effect of Δ9-tetrahydrocannabinol (THC). This psychoactive compound of cannabis induces a range of subjective, physical and mental reactions. The effect on heart rate is pronounced and complicates bloodflow-based neuroimaging of psychotropic effects of THC. In this study we investigated the effects of THC...
European Journal of Pharmacology
April 10, 2011
D Matthew Walentiny, Thomas F Gamage, Jonathan A Warner et al.
The endogenous cannabinoid system has been noted for its therapeutic potential, as well as the psychoactivity of cannabinoids such as Δ9-tetrahydrocannabinol (THC). However, less is known about the psychoactivity of anandamide (AEA), an endocannabinoid ligand. Thus, the goals of this study were to establish AEA as a discriminative stimulus in transgenic mice lacking fatty acid amide hydrolase...
Human psychopharmacology
April 2011
Kerri Alexandra Schoedel, Nancy Chen, Annie Hilliard et al.
This study aimed to evaluate the abuse potential and cognitive effects of nabiximols (Sativex, GW Pharma Ltd. Salisbury, UK), an oromucosal spray primarily containing delta‐9‐tetrahydrocannabinol (THC) and cannabidiol (CBD). This was a single‐dose, randomized, double‐blind, crossover study comparing nabiximols (4, 8, and 16 consecutive sprays: 10.8, 21.6, and 43.2 mg THC, respectively) with...
The Open Addiction Journal
March 29, 2011
Jacqui Rodgers
7 citations
The aim of this investigation was to extend our previous work and establish whether the findings reported previously of self reports of memory difficulties associated with ecstasy use can be replicated. A web-based methodology was adopted due to the significant advantages such techniques may confer when trying to reach a specialized population or address questions that people might be reluctant...