Journal of Psychoactive Drugs
May 28, 2022
Maja Kohek, Genís Ona, Michiel van Elk et al.
25 citations
Ayahuasca is a plant decoction in traditional Amazonian medicine. Its ritual use has been internationalized, leading to policy challenges that countries should address. This study evaluates the impact of regular ayahuasca ceremony participation on health by assessing the health status of 377 participants in ayahuasca ceremonies in the Netherlands using validated health indicators. A...
Journal of Psychoactive Drugs
May 4, 2022
Ismael Apud, Juan Scuro, Ignacio Carrera et al.
14 citations
The current article presents a mixed qualitative-quantitative observational study of the effect of ayahuasca ritual on subjective experiences and personality traits on participants of a center specialized in the treatment of substance use disorder in Uruguay. When comparing the psychological traits of ayahuasca participants to a control group, quantitative results using the...
Frontiers in Pharmacology
May 2, 2022
Ilana Berlowitz, Klemens Egger, Paul Cumming
32 citations
The monoamine oxidases (MAOs) are flavin-containing amine oxidoreductases responsible for metabolism of many biogenic amine molecules in the brain and peripheral tissues. Whereas serotonin is the preferred substrate of MAO-A, phenylethylamine is metabolized by MAO-B, and dopamine and tyramine are nearly ambivalent with respect to the two isozymes. β-Carboline alkaloids such as harmine,...
Revista de Antropologia
April 27, 2022
Marcos de Almeida Matos
3 citations
O artigo propõe examinar dois dos principais mitos pano relacionados à ayahuasca como transformações de uma série de outros mitos. Estabelecendo assim um conjunto de transformação, procura-se demonstrar que esses mitos estão intimamente ligados aos mitos que versam sobre a relação dos humanos com bandos de queixadas. Essa ligação pode ser compreendida à luz de uma hipótese bastante influente...
Biomedicines
April 26, 2022
Anna Szilágyi, Barbara Takács, Réka Szekeres et al.
10 citations
Ischemic eye diseases are major causes of vision impairment. Thus, potential retinoprotective effects of N’N-dimethyltryptamine (DMT) were investigated. To inhibit its rapid breakdown by monoamine-oxidase A (MAO-A) enzyme, DMT was co-administered with harmaline, a β-carboline in the Amazonian Ayahuasca brew. Using ligation, 60 min of ischemia was provoked in eyes of rats, followed by 7 days of...
Substance Use & Misuse
April 25, 2022
Dimitri Daldegan-Bueno, Dóra Révész, Paulo Rogério Morais et al.
15 citations
Background: Preliminary evidence suggests that long-term ayahuasca use is associated with better psychosocial outcomes and less drug use; however, available data on the association between ayahuasca intake frequency and psychosocial outcomes is limited. Objectives: We sought to characterize and investigate the association of regular ayahuasca use, as compared to non-regular use, on licit...
Cureus
April 20, 2022
Maryam Bayat Mokhtari, Moein Bayat Mokhtari, Blanca Z Rodriguez et al.
3 citations
Ayahuasca is a psychedelic blend originating from South America that has been used for hundreds of years by local tribes in ritualistic ceremonies. For the last few decades, its usage has expanded to North America in various mindfulness retreats that can benefit from its hallucinogenic properties. In this case report, our patient had attended a satanic ritual where he had consumed copious...
Molecules
April 13, 2022
Beatriz Werneck Lopes Santos, Daniel C. Moreira, Tatiana Karla Dos Santos Borges et al.
25 citations
Banisteriopsis caapi is used to prepare the psychoactive beverage ayahuasca, and both have therapeutic potential for the treatment of many central nervous system (CNS) conditions. This study aimed to isolate new bioactive compounds from B. caapi extract and evaluate their biological activity, and that of the known β-carboline components of the plant (harmine, harmaline, and tetrahydroharmine),...
Behavioural Brain Research
April 1, 2022
Dimitri Daldegan-Bueno, Vanessa Manchim Favaro, Paulo Rogério Morais et al.
10 citations
Considering the long-lasting effects of ayahuasca on the brain and emotional processing, the objective of this study was to evaluate the behavioural and neurobiological effects of repeated ayahuasca administration in an animal model of exploratory behaviour related to novel-environment anxiety. Male Wistar rats received water, 120, 240, 480 or 3600 mg/kg of resuspended freeze-dried ayahuasca by...
ACS Omega
April 1, 2022
Luisina Castelli Rodríguez, Andrés Mariño López, Guillermo Moyna et al.
28 citations
Ayahuasca is a psychedelic beverage originally from the Amazon rainforest used in different shamanic settings for medicinal, spiritual, and cultural purposes. It is prepared by boiling in water an admixture of the Amazonian vine Banisteriopsis caapi, which is a source of β-carboline alkaloids, with plants containing N,N-dimethyltryptamine, usually Psychotria viridis. While previous studies have...